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Quantitative Analysis of PiB-PET with FreeSurfer ROIs
Yi Su, Gina D’Angelo, Andrei G. Vlassenko, Gongfu Zhou, Abraham Z. Snyder, Daniel S. Marcus, Tyler Blazey, Jon J. Christensen, Shivangi Vora, John C. Morris, Mark A. Mintun, Tammie L.S. Benzinger. PLoS ONE, 2013-11-06
Topic: Risk, prevention and care in population studies
In vivo quantification of β-amyloid deposition using positron emission tomography is emerging as an important procedure for the early diagnosis of the Alzheimer's disease and is likely to play an important role in upcoming clinical trials of disease modifying agents. However, many groups use manually defined regions, which are non-standard across imaging centers. Analyses often are limited to a handful of regions because of the labor-intensive nature of manual region drawing. In this study, we developed an automatic image quantification protocol based on FreeSurfer, an automated whole brain segmentation tool, for quantitative analysis of amyloid images. Standard manual tracing and FreeSurfer-based analyses were performed in 77 participants including 67 cognitively normal individuals and 10 individuals with early Alzheimer's disease. The manual and FreeSurfer approaches yielded nearly identical estimates of amyloid burden (intraclass correlation = 0.98) as assessed by the mean cortical binding potential. An MRI test-retest study demonstrated excellent reliability of FreeSurfer based regional amyloid burden measurements. The FreeSurfer-based analysis also revealed that the majority of cerebral cortical regions accumulate amyloid in parallel, with slope of accumulation being the primary difference between regions.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Su, Y., D’Angelo, G., Vlassenko, A. G., Zhou, G., Snyder, A. Z., Marcus, D. S., et al. (2013). Quantitative Analysis of PiB-PET with FreeSurfer ROIs. PLoS ONE. https://doi.org/10.1371/journal.pone.0073377
Vancouver
Su Y, D’Angelo G, Vlassenko AG, Zhou G, Snyder AZ, Marcus DS, et al. Quantitative Analysis of PiB-PET with FreeSurfer ROIs. PLoS ONE. 2013. doi:10.1371/journal.pone.0073377. PMID: 24223109.
BibTeX
@article{su2013-24223109,
author = {Su, Yi and D’Angelo, Gina and Vlassenko, Andrei G. and Zhou, Gongfu and Snyder, Abraham Z. and Marcus, Daniel S. and Blazey, Tyler and Christensen, Jon J. and Vora, Shivangi and Morris, John C. and Mintun, Mark A. and Benzinger, Tammie L.S.},
title = {{Quantitative Analysis of PiB-PET with FreeSurfer ROIs}},
journal = {PLoS ONE},
year = {2013},
doi = {10.1371/journal.pone.0073377},
pmid = {24223109},
url = {https://doi.org/10.1371/journal.pone.0073377}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 12 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Why it matters
Developed an automated way to measure amyloid on PiB-PET scans using FreeSurfer brain segmentation, and compared it with manual tracing in 77 participants (67 cognitively normal and 10 with early Alzheimer's disease). The two approaches gave nearly identical estimates of amyloid burden, and most cortical regions accumulated amyloid in parallel.
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How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 46 of the 95 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (PLoS ONE) |
| Journal's citation record | 4 / 4 | PLoS ONE: journal h-index 594 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 248 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 16.5 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 3 / 6 | Cited 6.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 60 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Tammie L.S. Benzinger: h-index 98 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24223109) |
| Free to read | 2 / 2 | Free to read |
| Points | 46 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 46 of the 95 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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