This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

39/100

✓ Peer-reviewed alzhub usefulness score 39 out of 100. Risk factors

Topic: Amyloid, tau and blood-test diagnosis

Abstract INTRODUCTION Relationships between Alzheimer's disease neuropathology, residential neighborhood, and cognitive impairment remain incompletely understood. METHODS We examined whether residence within a disadvantaged neighborhood was associated with amyloid positron emission tomography (PET) positivity. We used data from the observational, multisite, Imaging Dementia–Evidence for Amyloid Scanning study that included cognitively impaired Medicare beneficiaries. Our secondary analysis examined multivariable‐adjusted associations between neighborhood disadvantage (measured by Area Deprivation Index [ADI] deciles 1–90 vs. 91–100 representing greatest disadvantage) and amyloid PET positivity. RESULTS Among 15,346 White, 829 Latino, 637 Black/African American, and 321 Asian individuals, 51% were female, mean age was 75.7 years, 535 (3.8%) resided in ADI 91 to 100 decile, and 61.6% were amyloid PET positive. The ADI 91‐100 decile was associated with lower odds of PET positivity by visual interpretation (odds ratio [OR] 0.80, 95% confidence interval [CI] 0.67–0.96, p ≤ .001) but not PET Centiloid value ≥ 40 versus ≤ 10 (OR 0.81, 95% CI 0.66–1.01, p = 0.060). CONCLUSION Residence in the most disadvantaged neighborhoods may be associated with lower amyloid pathology in cognitively impaired individuals.

Key findings

METHODS We examined whether residence within a disadvantaged neighborhood was associated with amyloid positron emission tomography (PET) positivity.
RESULTS Among 15,346 White, 829 Latino, 637 Black/African American, and 321 Asian individuals, 51% were female, mean age was 75.7 years, 535 (3.8%) resided in ADI 91 to 100 decile, and 61.6% were amyloid PET positive.
The ADI 91‐100 decile was associated with lower odds of PET positivity by visual interpretation (odds ratio [OR] 0.80, 95% confidence interval [CI] 0.67–0.96, p ≤ .001) but not PET Centiloid value ≥ 40 versus ≤ 10 (OR 0.81, 95% CI 0.66–1.01, p = 0.060).
CONCLUSION Residence in the most disadvantaged neighborhoods may be associated with lower amyloid pathology in cognitively impaired individuals.

Why it matters

People with cognitive impairment living in the most disadvantaged neighborhoods were less likely to have a positive amyloid PET scan by visual reading, though the result was not significant using a different amyloid measure. This suggests neighborhood disadvantage may be linked to lower amyloid pathology in this group.

New to this subject? Start with our plain-English guide: Risk factors, ranked →

Study details

Effect size3.8%; 61.6%; OR 0.81
Evidence strengthLow

How this study scored 39/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia Behavior & Socioeconomics of Aging)
Journal's citation record	0 / 4	Alzheimer s & Dementia Behavior & Socioeconomics of Aging: journal h-index 4 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 2 year(s) since 2026
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Gil D. Rabinovici: h-index 116 (OpenAlex, whole career)
Institution's track record	2 / 3	Washington University in St. Louis: institution h-index 1,962 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 12 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41816196)
Free to read	2 / 2	Free to read
Total	39 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Windon, C., Tsoy, E., Livaudais‐Toman, J., Neilands, T. B., Palmer, N. R., Heston, M. B., et al. (2026). Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals. Alzheimer s & Dementia Behavior & Socioeconomics of Aging. https://doi.org/10.1002/bsa3.70058

Vancouver

Windon C, Tsoy E, Livaudais‐Toman J, Neilands TB, Palmer NR, Heston MB, et al. Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals. Alzheimer s & Dementia Behavior & Socioeconomics of Aging. 2026. doi:10.1002/bsa3.70058. PMID: 41816196.

BibTeX

@article{windon2026-41816196,
  author  = {Windon, Charles and Tsoy, Elena and Livaudais‐Toman, Jennifer and Neilands, Torsten B. and Palmer, Nynikka R. and Heston, Margo B. and Johnson, Julene K. and Hanna, Lucy S. and others},
  title   = {{Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals}},
  journal = {Alzheimer s \& Dementia Behavior \& Socioeconomics of Aging},
  year    = {2026},
  doi     = {10.1002/bsa3.70058},
  pmid    = {41816196},
  url     = {https://doi.org/10.1002/bsa3.70058}
}

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 19.

Related studies in Risk factors

Also tagged “amyloid-beta”

1,339 studies in the library carry the topic tag “amyloid-beta”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,339 tagged studies.

Similar studies

More on Risk factors

See all studies in Risk factors →