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Identification of diabetes-related dementia: Longitudinal perfusion SPECT and amyloid PET studies
Fukasawa R, Hanyu H, Shimizu S, Kanetaka H, Sakurai H, Ishii K.. Journal of the neurological sciences, 2014-12-20
Topic: Amyloid, tau and blood-test diagnosis
Aims We attempted to identify a dementia subgroup with characteristics associated with diabetes mellitus (DM)-related metabolic abnormalities, referred to as diabetes-related dementia, using longitudinal single photon emission computed tomography (SPECT) and Pittsburgh compound-B (PiB) positron emission tomography (PET). Methods We classified 175 patients with clinically diagnosed Alzheimer disease (AD) and DM into 4 subgroups based on brain imaging in a 2013 study. Among them, we investigated follow-up SPECT studies in 29 patients of an AD group showing decreased regional cerebral blood flow (rCBF) of the parietotemporal lobe on initial SPECT and 18 patients of a diabetes-related dementia group showing neither decreased rCBF of the parietotemporal lobe nor cerebrovascular disease, which is strongly associated with DM-related factors. Eleven of them underwent PiB PET. Results Follow-up SPECT showed more profound rCBF reduction in the parietotemporal lobe and other areas of the AD group, whereas follow-up SPECT showed an rCBF reduction in small areas of the frontotemporal and limbic lobes of the diabetes-related dementia group. Six of 9 patients with diabetes-related dementia were negative or equivocal for PiB binding. Conclusion A subset of a dementia subgroup with characteristics predominantly associated with DM-related factors may underlie a pathophysiology different from AD, although these patients were clinically diagnosed as having AD. The identification of diabetes-related dementia may be necessary for considering an appropriate therapy and prevention in clinical practice.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Fukasawa, R., Hanyu, H., Shimizu, S., Kanetaka, H., Sakurai, H., & Ishii, K. (2015). Identification of diabetes-related dementia: Longitudinal perfusion SPECT and amyloid PET studies. Journal of the neurological sciences. https://doi.org/10.1016/j.jns.2014.12.023
Vancouver
Fukasawa R, Hanyu H, Shimizu S, Kanetaka H, Sakurai H, Ishii K. Identification of diabetes-related dementia: Longitudinal perfusion SPECT and amyloid PET studies. Journal of the neurological sciences. 2015. doi:10.1016/j.jns.2014.12.023. PMID: 25573776.
BibTeX
@article{fukasawa2015-25573776,
author = {Fukasawa, R. and Hanyu, H. and Shimizu, S. and Kanetaka, H. and Sakurai, H. and Ishii, K.},
title = {{Identification of diabetes-related dementia: Longitudinal perfusion SPECT and amyloid PET studies}},
journal = {Journal of the neurological sciences},
year = {2015},
doi = {10.1016/j.jns.2014.12.023},
pmid = {25573776},
url = {https://doi.org/10.1016/j.jns.2014.12.023}
}
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Key findings
- Aims We attempted to identify a dementia subgroup with characteristics associated with diabetes mellitus (DM)-related metabolic abnormalities, referred to as diabetes-related dementia, using longitudinal single photon emission computed tomography (SPECT) and Pittsburgh compound-B (PiB) positron emission tomography (PET).
- Among them, we investigated follow-up SPECT studies in 29 patients of an AD group showing decreased regional cerebral blood flow (rCBF) of the parietotemporal lobe on initial SPECT and 18 patients of a diabetes-related dementia group showing neither decreased rCBF of the parietotemporal lobe nor cerebrovascular disease, which is strongly associated with DM-related factors.
- Results Follow-up SPECT showed more profound rCBF reduction in the parietotemporal lobe and other areas of the AD group, whereas follow-up SPECT showed an rCBF reduction in small areas of the frontotemporal and limbic lobes of the diabetes-related dementia group.
- Conclusion A subset of a dementia subgroup with characteristics predominantly associated with DM-related factors may underlie a pathophysiology different from AD, although these patients were clinically diagnosed as having AD.
Why it matters
In this small longitudinal study, a subgroup of patients with diabetes-related dementia showed a different pattern of blood flow change and mostly did not show amyloid binding on PET, unlike the Alzheimer disease group. This suggests some dementia tied to diabetes-related factors may have a disease process different from Alzheimer disease.
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Study details
- Study designlongitudinal study
- Participants175
- Evidence strengthModerate
How this study scored 48/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the neurological sciences) |
| Journal's citation record | 2 / 4 | Journal of the Neurological Sciences: journal h-index 233 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 175 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 28 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.2 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 2 / 6 | Cited 1.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Kenji Ishii: h-index 63 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Tokyo Medical University: institution h-index 342 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25573776) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 48 / 100 | — |
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