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A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology
Matarin M, Salih DA, Yasvoina M, Cummings DM, Guelfi S, Liu W, Nahaboo Solim MA, Moens TG et al.. Cell reports, 2015-01-22
Topic: Brain proteins, microglia and lab models
We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene). Microarray data were validated by qPCR and by comparison to human studies, including genome-wide association study (GWAS) hits. Immune gene expression correlated tightly with plaques whereas synaptic genes correlated negatively with neurofibrillary tangles.
Key findings
- Microarray data were validated by qPCR and by comparison to human studies, including genome-wide association study (GWAS) hits.
- Immune gene expression correlated tightly with plaques whereas synaptic genes correlated negatively with neurofibrillary tangles.
- Network analysis of immune gene modules revealed six hub genes in hippocampus of amyloid mice, four in common with cortex.
- The hippocampal network in TAU mice was similar except that Trem2 had hub status only in amyloid mice.
Why it matters
This study built a database of genome-wide gene activity across the lifespan in mice engineered to develop either amyloid plaques (mutant human APP and/or PSEN1) or tau tangles (mutant human MAPT), and checked it with qPCR and against human studies, including GWAS hits. Immune genes rose and fell in step with plaques, synaptic genes moved opposite to tangles, and the immune-gene network analysis gave Trem2 hub status only in the amyloid mice. These are correlations in mice; the study tests no treatment and makes no claim about preventing or reversing Alzheimer's in people.
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Study details
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cell reports) |
| Journal's citation record | 3 / 4 | Cell Reports: journal h-index 321 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “transgenic”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 292 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 22.5 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 4 / 6 | Cited 17.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 34 other studies in this library |
| Still being cited | 2 / 4 | Cited 49 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Frances A. Edwards: h-index 29 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25620700) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Matarin, M., Salih, D. A., Yasvoina, M., Cummings, D. M., Guelfi, S., Liu, W., et al. (2015). A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. Cell reports. https://doi.org/10.1016/j.celrep.2014.12.041
Vancouver
Matarin M, Salih DA, Yasvoina M, Cummings DM, Guelfi S, Liu W, et al. A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. Cell reports. 2015. doi:10.1016/j.celrep.2014.12.041. PMID: 25620700.
BibTeX
@article{matarin2015-25620700,
author = {Matarin, M. and Salih, D. A. and Yasvoina, M. and Cummings, D. M. and Guelfi, S. and Liu, W. and Nahaboo Solim, M. A. and Moens, T. G. and others},
title = {{A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology}},
journal = {Cell reports},
year = {2015},
doi = {10.1016/j.celrep.2014.12.041},
pmid = {25620700},
url = {https://doi.org/10.1016/j.celrep.2014.12.041}
}
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