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47/100

✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain scans and imaging

Topic: Amyloid, tau and blood-test diagnosis

Background and purpose Prior MR imaging studies, primarily at 1.5T, established hippocampal atrophy as a biomarker for Alzheimer disease. 3T MR imaging offers a higher contrast and signal-to-noise ratio, yet distortions and intensity uniformity are harder to control. We applied our automated hippocampal segmentation technique to 1.5T and 3T MR imaging data, to determine whether hippocampal atrophy detection was enhanced at 3T. Materials and methods We analyzed baseline MR imaging data from 166 subjects from the Alzheimer's Disease Neuroimaging Initiative-1 (37 with Alzheimer disease, 76 with mild cognitive impairment, and 53 healthy controls) scanned at 1.5T and 3T. Using multiple linear regression, we analyzed the effect of clinical diagnosis on hippocampal radial distance, while adjusting for sex. 3D statistical maps were adjusted for multiple comparisons by using permutation-based statistics at a threshold of P Results Bilaterally significant radial distance differences in the areas corresponding to the cornu ammonis 1, cornu ammonis 2, and subiculum were detected for Alzheimer disease versus healthy controls and mild cognitive impairment versus healthy controls at 1.5T and more profoundly at 3T. Comparison of Alzheimer disease with mild cognitive impairment did not reveal significant differences at either field strength. Subjects who converted from mild cognitive impairment to Alzheimer disease within 3 years of the baseline scan versus nonconverters showed significant differences in the area corresponding to cornu ammonis 1 of the right hippocampus at 3T but not at 1.5T. Conclusions While hippocampal atrophy patterns in diagnostic comparisons were similar at 1.5T and 3T, 3T showed a superior signal-to-noise ratio and detected atrophy with greater effect size compared with 1.5T.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Chow, N., Hwang, K. S., Hurtz, S., Green, A. E., Somme, J. H., Thompson, P. M., et al. (2015). Comparing 3T and 1.5T MRI for mapping hippocampal atrophy in the Alzheimer's Disease Neuroimaging Initiative. AJNR. American journal of neuroradiology. https://doi.org/10.3174/ajnr.a4228

Vancouver

Chow N, Hwang KS, Hurtz S, Green AE, Somme JH, Thompson PM, et al. Comparing 3T and 1.5T MRI for mapping hippocampal atrophy in the Alzheimer's Disease Neuroimaging Initiative. AJNR. American journal of neuroradiology. 2015. doi:10.3174/ajnr.a4228. PMID: 25614473.

BibTeX

@article{chow2015-25614473,
  author  = {Chow, N. and Hwang, K. S. and Hurtz, S. and Green, A. E. and Somme, J. H. and Thompson, P. M. and Elashoff, D. A. and Jack, C. R. and others},
  title   = {{Comparing 3T and 1.5T MRI for mapping hippocampal atrophy in the Alzheimer's Disease Neuroimaging Initiative}},
  journal = {AJNR. American journal of neuroradiology},
  year    = {2015},
  doi     = {10.3174/ajnr.a4228},
  pmid    = {25614473},
  url     = {https://doi.org/10.3174/ajnr.a4228}
}

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Key findings

Using multiple linear regression, we analyzed the effect of clinical diagnosis on hippocampal radial distance, while adjusting for sex. 3D statistical maps were adjusted for multiple comparisons by using permutation-based statistics at a threshold of P < .01.
Comparison of Alzheimer disease with mild cognitive impairment did not reveal significant differences at either field strength.
Subjects who converted from mild cognitive impairment to Alzheimer disease within 3 years of the baseline scan versus nonconverters showed significant differences in the area corresponding to cornu ammonis 1 of the right hippocampus at 3T but not at 1.5T.
Conclusions While hippocampal atrophy patterns in diagnostic comparisons were similar at 1.5T and 3T, 3T showed a superior signal-to-noise ratio and detected atrophy with greater effect size compared with 1.5T.

Why it matters

This study compared 1.5T and 3T MRI for mapping hippocampal atrophy in people with Alzheimer's disease, mild cognitive impairment and healthy controls. It is about improving an imaging biomarker for diagnosis, not about treating, curing or preventing Alzheimer's disease.

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Study details

Participants166
Evidence strengthLow

How this study scored 47/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 45 of the 96 points we could judge it on, which is 47 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (AJNR. American journal of neuroradiology)
Journal's citation record	2 / 4	American Journal of Neuroradiology: journal h-index 182 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2015 — within 20 year(s) of the newest study here
Sample size	2 / 4	166 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 76 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	5.8 citations a year over 13 year(s) since 2015
Impact for its field and year	3 / 6	Cited 4.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	2 / 4	Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	OpenAlex's profile for last-listed author L.G. Apostolova holds only 7 work(s), too few to judge a track record — left out of this score
Institution's track record	2 / 3	University of California, Los Angeles: institution h-index 1,923 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 8 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 25614473)
Free to read	0 / 2	Behind a paywall — scores zero
Points	45 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 45 of the 96 points we could judge it on is 47 out of 100.
Total	47 / 100	—

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