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Optimal Target Region for Subject Classification on the Basis of Amyloid PET Images
Carbonell F, Zijdenbos AP, Charil A, Grand'Maison M, Bedell BJ, Alzheimer’s Disease Neuroimaging Initiative.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015-07-01
Topic: Amyloid, tau and blood-test diagnosis
Results We determined that several iterations of the discriminant analysis improved the classification of subjects into the AβL and AβH groups. We found that an ROI consisting of the posterior cingulate cortex/precuneus and the medial frontal cortex yielded optimal group separation and showed good stability across different reference regions and cognitive cohorts.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Carbonell, F., Zijdenbos, A. P., Charil, A., Grand'Maison, M., Bedell, B. J., & Alzheimer’s Disease Neuroimaging Initiative. (2015). Optimal Target Region for Subject Classification on the Basis of Amyloid PET Images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.115.158774
Vancouver
Carbonell F, Zijdenbos AP, Charil A, Grand'Maison M, Bedell BJ, Alzheimer’s Disease Neuroimaging Initiative. Optimal Target Region for Subject Classification on the Basis of Amyloid PET Images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015. doi:10.2967/jnumed.115.158774. PMID: 26135108.
BibTeX
@article{carbonell2015-26135108,
author = {Carbonell, F. and Zijdenbos, A. P. and Charil, A. and Grand'Maison, M. and Bedell, B. J. and {Alzheimer’s Disease Neuroimaging Initiative}},
title = {{Optimal Target Region for Subject Classification on the Basis of Amyloid PET Images}},
journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
year = {2015},
doi = {10.2967/jnumed.115.158774},
pmid = {26135108},
url = {https://doi.org/10.2967/jnumed.115.158774}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Results We determined that several iterations of the discriminant analysis improved the classification of subjects into the AβL and AβH groups.
- We found that an ROI consisting of the posterior cingulate cortex/precuneus and the medial frontal cortex yielded optimal group separation and showed good stability across different reference regions and cognitive cohorts.
Why it matters
This methods study found that a specific brain region combining the posterior cingulate cortex/precuneus and medial frontal cortex best separated people into low and high amyloid groups on amyloid PET. It concerns how to classify scans and does not test a treatment or prevention for Alzheimer disease.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Evidence strengthLow
How this study scored 33/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine) |
| Journal's citation record | 2 / 4 | Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 19 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.5 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 2 / 6 | Cited 1.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Barry J. Bedell: h-index 28 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Research Institute of the McGill University Health Centre: institution h-index 328 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26135108) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 33 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.2967/jnumed.115.158774
- PubMed: 26135108
- Original source →
- Free full text: jnm.snmjournals.org →
Full text: free to read — Unpaywall lists this copy as free to read: the link above (checked 10 Oct 2026).
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