This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

52/100

✓ Peer-reviewed alzhub usefulness score 52 out of 100. Cognitive tests and assessment

Topic: Brain proteins, microglia and lab models

Plain-language summary

Objective To assess reductions of cerebral glucose metabolism in Parkinson's disease (PD) with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET), and their associations with cognitive decline. Methods FDG-PET was performed on a cohort of 79 patients with newly diagnosed PD (mean disease duration 8 months) and 20 unrelated controls. PD participants were scanned while on their usual dopaminergic medication.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Firbank, M. J., Yarnall, A. J., Lawson, R. A., Duncan, G. W., Khoo, T. K., Petrides, G. S., et al. (2017). Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study. Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp-2016-313918

Vancouver

Firbank MJ, Yarnall AJ, Lawson RA, Duncan GW, Khoo TK, Petrides GS, et al. Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study. Journal of neurology, neurosurgery, and psychiatry. 2017. doi:10.1136/jnnp-2016-313918. PMID: 28315844.

BibTeX

@article{firbank2017-28315844,
  author  = {Firbank, M. J. and Yarnall, A. J. and Lawson, R. A. and Duncan, G. W. and Khoo, T. K. and Petrides, G. S. and O'Brien, J. T. and Barker, R. A. and others},
  title   = {{Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2017},
  doi     = {10.1136/jnnp-2016-313918},
  pmid    = {28315844},
  url     = {https://doi.org/10.1136/jnnp-2016-313918}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record lists 79 participants. Ask whether that is enough for the question, and who they were.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded moderate. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Moderate means the abstract mentions a cohort, case-control or longitudinal design. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

Methods FDG-PET was performed on a cohort of 79 patients with newly diagnosed PD (mean disease duration 8 months) and 20 unrelated controls.
PD participants were scanned while on their usual dopaminergic medication.
Cognitive testing was performed at baseline, and after 18 months using the Cognitive Drug Research (CDR) and Cambridge Neuropsychological Test Automated Battery (CANTAB) computerised batteries, the Mini-Mental State Examination (MMSE), and the Montreal Cognitive Assessment (MoCA).
We used statistical parametric mapping (SPM V.12) software to compare groups and investigate voxelwise correlations between FDG metabolism and cognitive score at baseline.

Why it matters

This study used FDG-PET to assess cerebral glucose metabolism in people newly diagnosed with Parkinson's disease and its association with cognitive decline over 18 months. It is about Parkinson's disease and cognition, not about treating, curing or preventing Alzheimer's disease.

Study details

Participants79
Evidence strengthModerate

How this study scored 52/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry)
Journal's citation record	3 / 4	Journal of Neurology Neurosurgery & Psychiatry: journal h-index 336 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	1 / 4	79 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 126 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	11.5 citations a year over 11 year(s) since 2017
Impact for its field and year	3 / 6	Cited 4.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	2 / 4	Cited 47 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author David John Burn: h-index 120 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Cambridge: institution h-index 1,973 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 8 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28315844)
Free to read	0 / 2	Behind a paywall — scores zero
Total	52 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies in the library that share something with this one. The line above each title says what.

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here.

Related studies in Cognitive tests and assessment from nearby years

Also tagged “lewy”

1,017 studies in the library carry the topic tag “lewy”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,017 tagged studies.

Studies sharing this one's topic tags

Similar studies

More on Cognitive tests and assessment

See all studies in Cognitive tests and assessment →