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Corpus callosum macro and microstructure in late-life depression
Louise Emsell, Christopher Adamson, François-Laurent De Winter, Thibo Billiet, Daan Christiaens, Filip Bouckaert, Katarzyna Adamczuk, Rik Vandenberghe et al.. Journal of affective disorders, 2017-06-27
Topic: Brain imaging, connectivity and assessment
Callosal AFD was lower in patients compared to controls. There were no group differences in CC thickness, surface area, FA, RD, nor whole brain or WMH volume. Late-onset of depression was associated with lower FA, higher RD and lower AFD. There were no associations between any imaging measures and psychotic features or depression severity as assessed by the geriatric depression scale. WMH volume was associated with lower FA and AFD, and higher RD in patients. LIMITATIONS: Patients were predominantly treatment-resistant. Measurements were limited to the mid-sagittal CC. dMRI analysis was performed on a smaller cohort, n=77. AFD was derived from low b-value data. Callosal structure is largely preserved in LLD. WMH burden may impact on CC microstructure in late-onset depression suggesting vascular pathology has additional deleterious effects in these patients.
Key findings
- Callosal AFD was lower in patients compared to controls.
- There were no group differences in CC thickness, surface area, FA, RD, nor whole brain or WMH volume.
- Late-onset of depression was associated with lower FA, higher RD and lower AFD.
- There were no associations between any imaging measures and psychotic features or depression severity as assessed by the geriatric depression scale.
- WMH volume was associated with lower FA and AFD, and higher RD in patients.
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Study details
- Participants77
- Evidence strengthModerate
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of affective disorders) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 77 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28672181) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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APA 7th
Emsell, L., Adamson, C., De Winter, F.-L., Billiet, T., Christiaens, D., Bouckaert, F., et al. (2017). Corpus callosum macro and microstructure in late-life depression. Journal of affective disorders. https://doi.org/10.1016/j.jad.2017.06.063
Vancouver
Emsell L, Adamson C, De Winter F.-L, Billiet T, Christiaens D, Bouckaert F, et al. Corpus callosum macro and microstructure in late-life depression. Journal of affective disorders. 2017. doi:10.1016/j.jad.2017.06.063. PMID: 28672181.
BibTeX
@article{emsell2017-28672181,
author = {Emsell, Louise and Adamson, Christopher and De Winter, François-Laurent and Billiet, Thibo and Christiaens, Daan and Bouckaert, Filip and Adamczuk, Katarzyna and Vandenberghe, Rik and others},
title = {{Corpus callosum macro and microstructure in late-life depression}},
journal = {Journal of affective disorders},
year = {2017},
doi = {10.1016/j.jad.2017.06.063},
pmid = {28672181},
url = {https://doi.org/10.1016/j.jad.2017.06.063}
}