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Motor speech signature of behavioral variant frontotemporal dementia: Refining the phenotype
Vogel AP, Poole ML, Pemberton H, Caverlé MWJ, Boonstra FMC, Low E, Darby D, Brodtmann A.. Neurology, 2017-07-21
Topic: Risk, prevention and care in population studies
Objective To provide a comprehensive description of motor speech function in behavioral variant frontotemporal dementia (bvFTD). Methods Forty-eight individuals (24 bvFTD and 24 age- and sex-matched healthy controls) provided speech samples. These varied in complexity and thus cognitive demand. Their language was assessed using the Progressive Aphasia Language Scale and verbal fluency tasks. Speech was analyzed perceptually to describe the nature of deficits and acoustically to quantify differences between patients with bvFTD and healthy controls. Cortical thickness and subcortical volume derived from MRI scans were correlated with speech outcomes in patients with bvFTD. Results Speech of affected individuals was significantly different from that of healthy controls. The speech signature of patients with bvFTD is characterized by a reduced rate (75%) and accuracy (65%) on alternating syllable production tasks, and prosodic deficits including reduced speech rate (45%), prolonged intervals (54%), and use of short phrases (41%). Groups differed on acoustic measures derived from the reading, unprepared monologue, and diadochokinetic tasks but not the days of the week or sustained vowel tasks. Variability of silence length was associated with cortical thickness of the inferior frontal gyrus and insula and speech rate with the precentral gyrus. Conclusions One in 8 patients presented with moderate speech timing deficits with a further two-thirds rated as mild or subclinical. Subtle but measurable deficits in prosody are common in bvFTD and should be considered during disease management. Language function correlated with speech timing measures derived from the unprepared monologue only.
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APA 7th
Vogel, A. P., Poole, M. L., Pemberton, H., Caverlé, M. W. J., Boonstra, F. M. C., Low, E., et al. (2017). Motor speech signature of behavioral variant frontotemporal dementia: Refining the phenotype. Neurology. https://doi.org/10.1212/wnl.0000000000004248
Vancouver
Vogel AP, Poole ML, Pemberton H, Caverlé MWJ, Boonstra FMC, Low E, et al. Motor speech signature of behavioral variant frontotemporal dementia: Refining the phenotype. Neurology. 2017. doi:10.1212/wnl.0000000000004248. PMID: 28733335.
BibTeX
@article{vogel2017-28733335,
author = {Vogel, A. P. and Poole, M. L. and Pemberton, H. and Caverlé, M. W. J. and Boonstra, F. M. C. and Low, E. and Darby, D. and Brodtmann, A.},
title = {{Motor speech signature of behavioral variant frontotemporal dementia: Refining the phenotype}},
journal = {Neurology},
year = {2017},
doi = {10.1212/wnl.0000000000004248},
pmid = {28733335},
url = {https://doi.org/10.1212/wnl.0000000000004248}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Results Speech of affected individuals was significantly different from that of healthy controls.
- Variability of silence length was associated with cortical thickness of the inferior frontal gyrus and insula and speech rate with the precentral gyrus.
Why it matters
This study described motor speech function in 24 individuals with behavioral variant frontotemporal dementia compared to healthy controls. It found speech was significantly different and correlated with brain regions, but it is about characterizing a different dementia, not treating Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 49 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.5 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 2 / 6 | Cited 2.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Amy G. Brodtmann: h-index 47 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The University of Melbourne: institution h-index 1,342 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28733335) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
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