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Impact of Postlabeling Delay on Arterial Spin-Labeling MRI-Based Measures of Cerebral Blood Flow in a Simultaneous PET/MRI Study of Aging
Jessie Fanglu Fu, Meher R. Juttukonda, Arun H. Garimella, Nathaniel David Mercaldo, Hsiao‐Ying Wey, Andrew N. Salvatore, Brad C. Dickerson, Julie C. Price. American Journal of Neuroradiology, 2026-04-23
Topic: Brain proteins, microglia and lab models
O]water PET were strongest for 1800 msec single-PLD and generally decreased with longer PLDs, except the occipital lobe, where all PLDs showed poor agreement. Multiple-PLD ASL showed similar correlation strengths as 2000 msec single-PLD. O]water PET, suggesting it may be an effective choice for studying CBF in aging and AD populations. While multiple-PLD ASL offered comparable performance, it did not confer notable benefits compared with the best-performing single-PLD under similar acquisition time constraints. These findings underscore the importance of PLD selection in ASL protocols in older or cognitively impaired cohorts and highlight the value of assessing intermediate-term reliability in longitudinal studies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Fu, J. F., Juttukonda, M. R., Garimella, A. H., Mercaldo, N. D., Wey, H., Salvatore, A. N., et al. (2026). Impact of Postlabeling Delay on Arterial Spin-Labeling MRI-Based Measures of Cerebral Blood Flow in a Simultaneous PET/MRI Study of Aging. American Journal of Neuroradiology. https://doi.org/10.3174/ajnr.a9130
Vancouver
Fu JF, Juttukonda MR, Garimella AH, Mercaldo ND, Wey H, Salvatore AN, et al. Impact of Postlabeling Delay on Arterial Spin-Labeling MRI-Based Measures of Cerebral Blood Flow in a Simultaneous PET/MRI Study of Aging. American Journal of Neuroradiology. 2026. doi:10.3174/ajnr.a9130. PMID: 42025299.
BibTeX
@article{fu2026-42025299,
author = {Fu, Jessie Fanglu and Juttukonda, Meher R. and Garimella, Arun H. and Mercaldo, Nathaniel David and Wey, Hsiao‐Ying and Salvatore, Andrew N. and Dickerson, Brad C. and Price, Julie C.},
title = {{Impact of Postlabeling Delay on Arterial Spin-Labeling MRI-Based Measures of Cerebral Blood Flow in a Simultaneous PET/MRI Study of Aging}},
journal = {American Journal of Neuroradiology},
year = {2026},
doi = {10.3174/ajnr.a9130},
pmid = {42025299},
url = {https://doi.org/10.3174/ajnr.a9130}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- O]water PET were strongest for 1800 msec single-PLD and generally decreased with longer PLDs, except the occipital lobe, where all PLDs showed poor agreement.
- Multiple-PLD ASL showed similar correlation strengths as 2000 msec single-PLD.
- O]water PET, suggesting it may be an effective choice for studying CBF in aging and AD populations.
- While multiple-PLD ASL offered comparable performance, it did not confer notable benefits compared with the best-performing single-PLD under similar acquisition time constraints.
- These findings underscore the importance of PLD selection in ASL protocols in older or cognitively impaired cohorts and highlight the value of assessing intermediate-term reliability in longitudinal studies.
Why it matters
This study compared different timing settings for a type of MRI that measures blood flow in the brain, finding that a 1800 msec delay correlated best with PET blood flow measures. It is a methods study about imaging technique and does not test any treatment, cure, or prevention.
New to this subject? Start with our plain-English guide: Brain scans & tests →
Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 49/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American Journal of Neuroradiology) |
| Journal's citation record | 2 / 4 | American Journal of Neuroradiology: journal h-index 182 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.5 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 3 / 6 | Cited 4.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Julie C. Price: h-index 83 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42025299) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
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