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54/100

✓ Peer-reviewed alzhub usefulness score 54 out of 100. Mild cognitive impairment

Topic: Brain proteins, microglia and lab models

The choroid plexus (ChP) is a major source of cerebrospinal fluid (CSF) production, with a direct and indirect role in protein clearance, and pathogenesis of Alzheimer's disease (AD). Here, we tested the link between the ChP volume and levels of CSF proteins in 2 data sets of (i) healthy controls, mild cognitive impairment (MCI), and AD patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) (N = 509), and (ii) healthy controls and Parkinson's disease (PD) patients from the Parkinson's Progression Markers Initiative (N = 302). All patients had baseline CSF proteins (amyloid-β, total and phosphorylated-tau and α-synuclein (only in Parkinson's Progression Markers Initiative)). ChP was automatically segmented on 3T structural T1-weighted MRIs. We found negative associations between ChP volume and CSF proteins, which were stronger in healthy controls, early-MCI patients, and PD patients compared with late-MCI and AD patients. Further grouping of patients of ADNI dataset into amyloid-positive and amyloid-negative based on their florbetapir (AV45) PET imaging showed that the association between ChP volume and CSF proteins (t/p-tau) was lower in amyloid-positive group. Our findings support the possible role of ChP in the clearance of CSF proteins, provide evidence for ChP dysfunction in AD, and suggest the need to account for the ChP volume in future studies of CSF-based biomarkers.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Tadayon, E., Pascual-Leone, A., Press, D., Santarnecchi, E., & Alzheimer's Disease Neuroimaging Initiative. (2020). Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2020.01.005

Vancouver

Tadayon E, Pascual-Leone A, Press D, Santarnecchi E, Alzheimer's Disease Neuroimaging Initiative. Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease. Neurobiology of aging. 2020. doi:10.1016/j.neurobiolaging.2020.01.005. PMID: 32107064.

BibTeX

@article{tadayon2020-32107064,
  author  = {Tadayon, E. and Pascual-Leone, A. and Press, D. and Santarnecchi, E. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease}},
  journal = {Neurobiology of aging},
  year    = {2020},
  doi     = {10.1016/j.neurobiolaging.2020.01.005},
  pmid    = {32107064},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2020.01.005}
}

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Key findings

We found negative associations between ChP volume and CSF proteins, which were stronger in healthy controls, early-MCI patients, and PD patients compared with late-MCI and AD patients.
Further grouping of patients of ADNI dataset into amyloid-positive and amyloid-negative based on their florbetapir (AV45) PET imaging showed that the association between ChP volume and CSF proteins (t/p-tau) was lower in amyloid-positive group.
Our findings support the possible role of ChP in the clearance of CSF proteins, provide evidence for ChP dysfunction in AD, and suggest the need to account for the ChP volume in future studies of CSF-based biomarkers.

Why it matters

In two large datasets, larger choroid plexus volume was associated with lower cerebrospinal fluid protein levels, and this association was weaker in late mild cognitive impairment and Alzheimer's disease patients and in amyloid-positive people. This supports a possible role for the choroid plexus in protein clearance but does not show that any treatment, cure, or prevention works.

Study details

Participants509
Evidence strengthLow

How this study scored 54/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neurobiology of aging)
Journal's citation record	3 / 4	Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2020 — within 10 year(s) of the newest study here
Sample size	2 / 4	509 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 146 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	18.2 citations a year over 8 year(s) since 2020
Impact for its field and year	3 / 6	Cited 4.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	3 / 4	Cited 103 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Emiliano Santarnecchi: h-index 60 (OpenAlex, whole career)
Institution's track record	3 / 3	Harvard University: institution h-index 3,235 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 6 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 32107064)
Free to read	0 / 2	Behind a paywall — scores zero
Total	54 / 100	—

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