Evaluation of the relationships between inflammatory markers and processing speed in recent-onset and chronic schizophrenia: a polygenic risk score study
М. В. Алфимова, Victoria Plakunova, Вера Евгеньевна Голимбет. European Psychiatry, 2026-06-01
Topic: Brain proteins, microglia and lab models
Hierarchical linear regression was used to assess an incremental contribution of the set of inflammatory markers’ PRS to explaining VF variance compared to the null model. Results The immune-related PRSs did not significantly improve the VF prediction in either group (RoSz: p=0.38, ΔR 2 =0.02; CrSz: p=0.47, ΔR 2 =0.02). Remarkedly, SZ-PRS was related to VF in the RoSz group (β=-1.53, SE=0.75, bootstrapping-based bias corrected accelerated (bca) p=0.04), while AD-PRS (β=-1.83, SE=0.89, bca p=0.03) and negative symptoms (β=-0.52, SE=0.14, bca p<0.001) were significant predictors of VF in the CrSz group. Conclusions No significant association was found between PRS of CRP and IL-6 levels with verbal fluency in either recent-onset or chronic Sz. One explanation for the negative result may be that inflammation has a minor effect on the variability of cognitive deficits compared to other factors acting at different stages of the disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Алфимова, М. В., Plakunova, V., & Голимбет, В. Е. (2026). Evaluation of the relationships between inflammatory markers and processing speed in recent-onset and chronic schizophrenia: a polygenic risk score study. European Psychiatry. https://doi.org/10.1192/j.eurpsy.2026.11269
Vancouver
Алфимова МВ, Plakunova V, Голимбет ВЕ. Evaluation of the relationships between inflammatory markers and processing speed in recent-onset and chronic schizophrenia: a polygenic risk score study. European Psychiatry. 2026. doi:10.1192/j.eurpsy.2026.11269.
BibTeX
@article{study2026-13971599,
author = {Алфимова, М. В. and Plakunova, Victoria and Голимбет, Вера Евгеньевна},
title = {{Evaluation of the relationships between inflammatory markers and processing speed in recent-onset and chronic schizophrenia: a polygenic risk score study}},
journal = {European Psychiatry},
year = {2026},
doi = {10.1192/j.eurpsy.2026.11269},
url = {https://doi.org/10.1192/j.eurpsy.2026.11269}
}
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Key findings
- Hierarchical linear regression was used to assess an incremental contribution of the set of inflammatory markers’ PRS to explaining VF variance compared to the null model.
- Results The immune-related PRSs did not significantly improve the VF prediction in either group (RoSz: p=0.38, ΔR 2 =0.02; CrSz: p=0.47, ΔR 2 =0.02).
- Remarkedly, SZ-PRS was related to VF in the RoSz group (β=-1.53, SE=0.75, bootstrapping-based bias corrected accelerated (bca) p=0.04), while AD-PRS (β=-1.83, SE=0.89, bca p=0.03) and negative symptoms (β=-0.52, SE=0.14, bca p<0.001) were significant predictors of VF in the CrSz group.
- Conclusions No significant association was found between PRS of CRP and IL-6 levels with verbal fluency in either recent-onset or chronic Sz.
- One explanation for the negative result may be that inflammation has a minor effect on the variability of cognitive deficits compared to other factors acting at different stages of the disease.
Why it matters
In people with recent-onset or chronic schizophrenia, genetic scores for inflammatory markers did not significantly improve prediction of verbal fluency. An Alzheimer polygenic risk score was a significant predictor of verbal fluency only in the chronic schizophrenia group, but this finding is about schizophrenia, not Alzheimer disease treatment or prevention.
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Study details
- Participants135
- Evidence strengthLow
How this study scored 35/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on institution's track record, so that was left out: it earned 34 of the 97 points we could judge it on, which is 35 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European Psychiatry) |
| Journal's citation record | 1 / 4 | European Psychiatry: journal h-index 143 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 135 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Вера Евгеньевна Голимбет: h-index 29 (OpenAlex, whole career) |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 34 / 97 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 34 of the 97 points we could judge it on is 35 out of 100. |
| Total | 35 / 100 | — |
What each of these 20 components measures, and what this score is not →
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