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65/100

✓ Peer-reviewed alzhub usefulness score 65 out of 100. Prevention and risk

Topic: Risk, prevention and care in population studies

Results Among 1943 parent trial participants who were assessed for eligibility, 983 underwent at least 1 magnetic resonance imaging or positron emission tomography scanning session. Intervention group differences were not associated with or moderated by Aβ status or accumulation. Lower baseline HC volume was associated with greater cognitive benefit for participants in the structured group vs the self-guided group (lower HC: 0.077 SD; 95% CI, 0.022 to 0.132; higher HC: 0.002 SD; 95% CI, -0.037 to 0.041; interaction P = .03). Conclusion and relevance This study found that a high-intensity multidomain lifestyle intervention did not affect brain biomarker trajectories and was not associated with Aβ pathology, but older adults with specific at-risk brain characteristics, including lower baseline HC volume, showed a greater cognitive benefit of the structured intervention.

Key findings

Results Among 1943 parent trial participants who were assessed for eligibility, 983 underwent at least 1 magnetic resonance imaging or positron emission tomography scanning session.
Intervention group differences were not associated with or moderated by Aβ status or accumulation.
Lower baseline HC volume was associated with greater cognitive benefit for participants in the structured group vs the self-guided group (lower HC: 0.077 SD; 95% CI, 0.022 to 0.132; higher HC: 0.002 SD; 95% CI, -0.037 to 0.041; interaction P = .03).
Conclusion and relevance This study found that a high-intensity multidomain lifestyle intervention did not affect brain biomarker trajectories and was not associated with Aβ pathology, but older adults with specific at-risk brain characteristics, including lower baseline HC volume, showed a greater cognitive benefit of the structured intervention.

Why it matters

In this imaging study, a high-intensity multidomain lifestyle intervention did not affect brain biomarker trajectories and was not associated with amyloid pathology. However, older adults with lower baseline hippocampal volume showed greater cognitive benefit from the structured intervention than from the self-guided one.

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Study details

Study designRCT
Participants983
Effect sizeCognitive benefit of structured vs self-guided: 0.077 SD (95% CI 0.022-0.132) with lower hippocampal volume vs 0.002 SD (95% CI -0.037 to 0.041) with higher
Evidence strengthModerate

Limitations

Ancillary study not powered for imaging endpoints; both arms received an active intervention; two-year window is short for biomarker change; subgroup interaction findings need replication.

How this study scored 65/100

Published in a leading specialty journal, and it is a randomised controlled trial. We have no data on free to read, so that was left out: it earned 64 of the 98 points we could judge it on, which is 65 out of 100.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA Neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	11 / 12	A randomised controlled trial
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	2 / 4	983 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	1 / 2	Randomised (as stated in the record)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 2 year(s) since 2026
Impact for its field and year	4 / 6	Cited 9.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Susan M. Landau: h-index 57 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Michigan: institution h-index 2,240 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 9 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 42008251)
Free to read	— / 2	Access not recorded — left out of this score
Points	64 / 98	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 64 of the 98 points we could judge it on is 65 out of 100.
Total	65 / 100	—

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Read the original

Full text: free to read — PubMed Central lists this copy as free to read: the link above (checked 10 Oct 2026).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Harrison, T. M., Harvey, D. J., Chadwick, T., Chao, Y., Taggett, J., Maillard, P., et al. (2026). Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2026.0832

Vancouver

Harrison TM, Harvey DJ, Chadwick T, Chao Y, Taggett J, Maillard P, et al. Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study. JAMA Neurology. 2026. doi:10.1001/jamaneurol.2026.0832. PMID: 42008251.

BibTeX

@article{harrison2026-42008251,
  author  = {Harrison, T. M. and Harvey, D. J. and Chadwick, T. and Chao, Y. and Taggett, J. and Maillard, P. and Lovato, L. and Farias, S. T. and Papp, K. V. and Lockhart, S. N. and others},
  title   = {{Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study}},
  journal = {JAMA Neurology},
  year    = {2026},
  doi     = {10.1001/jamaneurol.2026.0832},
  pmid    = {42008251},
  url     = {https://doi.org/10.1001/jamaneurol.2026.0832}
}

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