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43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Lewy body dementia

Topic: Brain proteins, microglia and lab models

Across both regions, no evidence of reduced total neuronal density was observed, but a modest reduction in parvalbumin interneurons was observed in the cingulate gyrus, and there were only modest reductions in some synaptic markers in DLB. LB burden was markedly variable across DLB cases but was not associated with any synaptic marker abundance or neuronal density. Taken together, these findings do not support an association between LB density and neuronal or synaptic loss in DLB, even in regions with particularly high burdens of LBs, such as the cingulate gyrus. These findings suggest that the link between αSyn proteinopathy and disease requires further investigation.

Key findings

Across both regions, no evidence of reduced total neuronal density was observed, but a modest reduction in parvalbumin interneurons was observed in the cingulate gyrus, and there were only modest reductions in some synaptic markers in DLB.
LB burden was markedly variable across DLB cases but was not associated with any synaptic marker abundance or neuronal density.
Taken together, these findings do not support an association between LB density and neuronal or synaptic loss in DLB, even in regions with particularly high burdens of LBs, such as the cingulate gyrus.
These findings suggest that the link between αSyn proteinopathy and disease requires further investigation.

Why it matters

This study found no evidence of reduced total neuronal density and only modest reductions in some synaptic markers in dementia with Lewy bodies, and Lewy body burden was not associated with any synaptic marker abundance or neuronal density. The authors conclude that the link between α-synuclein proteinopathy and disease requires further investigation, and no treatment, cure or prevention is reported.

Study details

Participants20
Evidence strengthLow

How this study scored 43/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neuropathology and Applied Neurobiology)
Journal's citation record	1 / 4	Neuropathology and Applied Neurobiology: journal h-index 143 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	1 / 4	20 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 2 year(s) since 2026
Impact for its field and year	4 / 6	Cited 8.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Daniel Erskine: h-index 28 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Göttingen: institution h-index 934 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 7 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 42270085)
Free to read	2 / 2	Free to read
Total	43 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

APA 7th

Hawksworth, J. I., Kirkby‐Geddes, E., Thom, S., O'Neill, J., Ikwue, A., Wood, L., et al. (2026). Lewy Bodies Are Not Associated With Neuronal or Synaptic Loss in Dementia With Lewy Bodies. Neuropathology and Applied Neurobiology. https://doi.org/10.1111/nan.70085

Vancouver

Hawksworth JI, Kirkby‐Geddes E, Thom S, O'Neill J, Ikwue A, Wood L, et al. Lewy Bodies Are Not Associated With Neuronal or Synaptic Loss in Dementia With Lewy Bodies. Neuropathology and Applied Neurobiology. 2026. doi:10.1111/nan.70085. PMID: 42270085.

BibTeX

@article{hawksworth2026-42270085,
  author  = {Hawksworth, Jade I. and Kirkby‐Geddes, Eddie and Thom, Searlait and O'Neill, Joe and Ikwue, Amelia and Wood, Lucy and Outeiro, Tiago F. and Erskine, Daniel},
  title   = {{Lewy Bodies Are Not Associated With Neuronal or Synaptic Loss in Dementia With Lewy Bodies}},
  journal = {Neuropathology and Applied Neurobiology},
  year    = {2026},
  doi     = {10.1111/nan.70085},
  pmid    = {42270085},
  url     = {https://doi.org/10.1111/nan.70085}
}

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