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Limbic-predominant age-related TDP-43 encephalopathy in Black and White decedents
Sukriti Nag, Lisa L Barnes, Lei Yu, Robert S Wilson, David A Bennett, Julie A Schneider. Neurology, 2020-08-05
Topic: Brain imaging, connectivity and assessment
The overall frequency of LATE-NC in Black and White decedents was similar (40.8% vs 45.4%). Black decedents with moderate/severe LATE-NC were older, had significantly lower global cognition scores, particularly in memory domains, and had higher frequency of Alzheimer disease, hippocampal sclerosis, and cerebral amyloid angiopathy than the LATE-NC none/mild group. LATE-NC in Black decents was independently associated with impaired global cognition, episodic and semantic memory, and visuospatial abilities. There were no racial differences in clinical features or pathologic distribution of LATE-NC except for a significant increase in the mean cytoplasmic inclusions in the entorhinal and mid temporal cortices in White compared to Black decedents. In addition, no racial differences in the cognitive profiles or the odds of dementia were observed in Black vs White decedents. Consistent with findings in White decedents, LATE-NC in Black decedents is associated with impaired cognition, including memory domains.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Nag, S., Barnes, L. L., Yu, L., Wilson, R. S., Bennett, D. A., & Schneider, J. A. (2020). Limbic-predominant age-related TDP-43 encephalopathy in Black and White decedents. Neurology. https://doi.org/10.1212/wnl.0000000000010602
Vancouver
Nag S, Barnes LL, Yu L, Wilson RS, Bennett DA, Schneider JA. Limbic-predominant age-related TDP-43 encephalopathy in Black and White decedents. Neurology. 2020. doi:10.1212/wnl.0000000000010602. PMID: 32759188.
BibTeX
@article{nag2020-32759188,
author = {Nag, Sukriti and Barnes, Lisa L and Yu, Lei and Wilson, Robert S and Bennett, David A and Schneider, Julie A},
title = {{Limbic-predominant age-related TDP-43 encephalopathy in Black and White decedents}},
journal = {Neurology},
year = {2020},
doi = {10.1212/wnl.0000000000010602},
pmid = {32759188},
url = {https://doi.org/10.1212/wnl.0000000000010602}
}
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Key findings
- The overall frequency of LATE-NC in Black and White decedents was similar (40.8% vs 45.4%).
- Black decedents with moderate/severe LATE-NC were older, had significantly lower global cognition scores, particularly in memory domains, and had higher frequency of Alzheimer disease, hippocampal sclerosis, and cerebral amyloid angiopathy than the LATE-NC none/mild group.
- LATE-NC in Black decents was independently associated with impaired global cognition, episodic and semantic memory, and visuospatial abilities.
- There were no racial differences in clinical features or pathologic distribution of LATE-NC except for a significant increase in the mean cytoplasmic inclusions in the entorhinal and mid temporal cortices in White compared to Black decedents.
- In addition, no racial differences in the cognitive profiles or the odds of dementia were observed in Black vs White decedents.
Study details
- Study designlongitudinal study
- Participants76
- Effect size40.8%; 45.4%
- Evidence strengthModerate
How this study scored 70/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 39 of the 56 points we could judge it on, which is 70 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 76 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32759188) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 39 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 39 of the 56 points we could judge it on is 70 out of 100. |
| Total | 70 / 100 | — |
What each of these 20 components measures, and what this score is not →
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