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Noninvasive Antemortem Detection of Retinal Prions by a Fluorescent Tracer
Patricia Aguilar-Calvo, Alejandro M Sevillano, Suhail Rasool, Kevin J Cao, Lyndsay M Randolph, Robert A Rissman, Stella T Sarraf, Jerry Yang et al.. Journal of Alzheimer's disease : JAD, 2022
Topic: Plasma and spinal-fluid biomarkers
We report that by early prion disease (50% timepoint), discrete fluorescent foci appeared adjacent to the optic disc. By later timepoints, the fluorescent foci surrounded the optic disc and tracked along retinal vasculature. The progression of perivascular amyloid can be directly monitored in the eye by live imaging, illustrating the utility of this technology for diagnosing and monitoring the progression of cerebral amyloid angiopathy.
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APA 7th
Aguilar-Calvo, P., Sevillano, A. M., Rasool, S., Cao, K. J., Randolph, L. M., Rissman, R. A., et al. (2022). Noninvasive Antemortem Detection of Retinal Prions by a Fluorescent Tracer. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-220314
Vancouver
Aguilar-Calvo P, Sevillano AM, Rasool S, Cao KJ, Randolph LM, Rissman RA, et al. Noninvasive Antemortem Detection of Retinal Prions by a Fluorescent Tracer. Journal of Alzheimer's disease : JAD. 2022. doi:10.3233/jad-220314. PMID: 35754278.
BibTeX
@article{aguilarcalvo2022-35754278,
author = {Aguilar-Calvo, Patricia and Sevillano, Alejandro M and Rasool, Suhail and Cao, Kevin J and Randolph, Lyndsay M and Rissman, Robert A and Sarraf, Stella T and Yang, Jerry and others},
title = {{Noninvasive Antemortem Detection of Retinal Prions by a Fluorescent Tracer}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2022},
doi = {10.3233/jad-220314},
pmid = {35754278},
url = {https://doi.org/10.3233/jad-220314}
}
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Key findings
- We report that by early prion disease (50% timepoint), discrete fluorescent foci appeared adjacent to the optic disc.
- By later timepoints, the fluorescent foci surrounded the optic disc and tracked along retinal vasculature.
- The progression of perivascular amyloid can be directly monitored in the eye by live imaging, illustrating the utility of this technology for diagnosing and monitoring the progression of cerebral amyloid angiopathy.
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Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 57/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 32 of the 56 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35754278) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 32 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 32 of the 56 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
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