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Cognitive Reserve Modulates Brain Structure and Cortical Architecture in the Alzheimer's Disease
Laura Serra, Giulia Giancaterino, Giovanni Giulietti, Laura Petrosini, Carlotta Di Domenico, Camillo Marra, Carlo Caltagirone, Andrea Bassi et al.. Journal of Alzheimer's disease : JAD, 2022
Topic: Brain imaging, connectivity and assessment
aMCI-HCR compared to aMCI-LCR patients showed significant decrease of CTh in the right temporal and in the left prefrontal lobe. Moreover, they showed increased FD in the right temporal and in the left temporo-parietal lobes. Patients with AD-HCR showed reduced CTh in several brain areas and reduced FD in the left temporal cortices when compared with AD-LCR subjects. HS-HCR showed a significant increase of CTh in prefrontal areas bilaterally, and in the right parieto-occipital cortices. Finally, aMCI-HCR showed significant positive associations between brain measures and memory and executive performance. CR modulates the cortical architecture at pre-dementia stage only. Indeed, only patients with aMCI showed both atrophy (likely due to neurodegeneration) alongside richer brain folding (likely due to reserve mechanisms) in temporo-parietal areas. This opposite trend was not observed in AD and HS. Our data confirm the existence of a limited time-window for CR modulation at the aMCI stage.
Key findings
- aMCI-HCR compared to aMCI-LCR patients showed significant decrease of CTh in the right temporal and in the left prefrontal lobe.
- Moreover, they showed increased FD in the right temporal and in the left temporo-parietal lobes.
- Patients with AD-HCR showed reduced CTh in several brain areas and reduced FD in the left temporal cortices when compared with AD-LCR subjects.
- HS-HCR showed a significant increase of CTh in prefrontal areas bilaterally, and in the right parieto-occipital cortices.
- Finally, aMCI-HCR showed significant positive associations between brain measures and memory and executive performance.
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Study details
- Participants278
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 278 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35964192) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Serra, L., Giancaterino, G., Giulietti, G., Petrosini, L., Di Domenico, C., Marra, C., et al. (2022). Cognitive Reserve Modulates Brain Structure and Cortical Architecture in the Alzheimer's Disease. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-220377
Vancouver
Serra L, Giancaterino G, Giulietti G, Petrosini L, Di Domenico C, Marra C, et al. Cognitive Reserve Modulates Brain Structure and Cortical Architecture in the Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022. doi:10.3233/jad-220377. PMID: 35964192.
BibTeX
@article{serra2022-35964192,
author = {Serra, Laura and Giancaterino, Giulia and Giulietti, Giovanni and Petrosini, Laura and Di Domenico, Carlotta and Marra, Camillo and Caltagirone, Carlo and Bassi, Andrea and others},
title = {{Cognitive Reserve Modulates Brain Structure and Cortical Architecture in the Alzheimer's Disease}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2022},
doi = {10.3233/jad-220377},
pmid = {35964192},
url = {https://doi.org/10.3233/jad-220377}
}
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