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Association Between Plasma Phosphorylated Tau-217 and Cognition in Parkinson's Disease
Trycia Kouchache, Tevy Chan, Sophie Sun, Lang Liu, Aline Delva, Ziv Gan-Or, Pedro Rosa-Neto, Jean-François Gagnon et al.. Movement disorders : official journal of the Movement Disorder Society, 2026-07-19
Topic: Plasma and spinal-fluid biomarkers
No significant differences in p-tau217, GFAP and NfL level were observed between groups (pFDR > 0.08). Higher p-tau217 was associated with worse visuospatial function and greater self-reported cognitive impairment, but these associations did not survive correction (pFDR > 0.08). There was no association with cognitive impairment (pFDR > 0.08). These results suggest that co-morbid AD pathology is not a major contributor to early cognitive changes in this sample of PD patients without dementia. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Kouchache, T., Chan, T., Sun, S., Liu, L., Delva, A., Gan-Or, Z., et al. (2026). Association Between Plasma Phosphorylated Tau-217 and Cognition in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. https://doi.org/10.1002/mds.70400
Vancouver
Kouchache T, Chan T, Sun S, Liu L, Delva A, Gan-Or Z, et al. Association Between Plasma Phosphorylated Tau-217 and Cognition in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2026. doi:10.1002/mds.70400. PMID: 42473272.
BibTeX
@article{kouchache2026-42473272,
author = {Kouchache, Trycia and Chan, Tevy and Sun, Sophie and Liu, Lang and Delva, Aline and Gan-Or, Ziv and Rosa-Neto, Pedro and Gagnon, Jean-François and others},
title = {{Association Between Plasma Phosphorylated Tau-217 and Cognition in Parkinson's Disease}},
journal = {Movement disorders : official journal of the Movement Disorder Society},
year = {2026},
doi = {10.1002/mds.70400},
pmid = {42473272},
url = {https://doi.org/10.1002/mds.70400}
}
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Key findings
- No significant differences in p-tau217, GFAP and NfL level were observed between groups (pFDR > 0.08).
- Higher p-tau217 was associated with worse visuospatial function and greater self-reported cognitive impairment, but these associations did not survive correction (pFDR > 0.08).
- There was no association with cognitive impairment (pFDR > 0.08).
- These results suggest that co-morbid AD pathology is not a major contributor to early cognitive changes in this sample of PD patients without dementia. © 2026 The Author(s).
- Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 25 of the 56 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Movement disorders : official journal of the Movement Disorder Society) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42473272) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 25 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 25 of the 56 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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