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Integrated Proteomic and Phosphoproteomic Profiling Reveals Distinct Disease- and Age-Related Molecular Alterations in the Retina and Hippocampus of APP/PS1/MAPT Mice
Mei X, Cui W, Zhao Z, Wang M, Lin Y, Xu J, Qiu C, Wu T.. Research Square, 2026-07-20
Topic: Genetics and APOE
The retina displayed earlier and broader AD-related molecular alterations than the hippocampus. Retinal AD-related DEPs, DPPs and kinase perturbations were enriched in metabolic and molecular pathways, whereas hippocampal AD-related molecules were associated with synapse/axon/neuroactive ligand-related pathways. Two tissues shared a restricted set of dysregulated molecules, including RTN4, HDAC6 and PALS1_S84. This study establishes a synchronized dual-tissue, dual-omics framework for dissecting AD-related pathology and age-associated remodeling, providing a new insight into eye-brain molecular crosstalk and offering a theoretical basis for retina-based, noninvasive early diagnosis of AD.
Key findings
- The retina displayed earlier and broader AD-related molecular alterations than the hippocampus.
- Retinal AD-related DEPs, DPPs and kinase perturbations were enriched in metabolic and molecular pathways, whereas hippocampal AD-related molecules were associated with synapse/axon/neuroactive ligand-related pathways.
- Two tissues shared a restricted set of dysregulated molecules, including RTN4, HDAC6 and PALS1_S84.
- This study establishes a synchronized dual-tissue, dual-omics framework for dissecting AD-related pathology and age-associated remodeling, providing a new insight into eye-brain molecular crosstalk and offering a theoretical basis for retina-based, noninvasive early diagnosis of AD.
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Study details
- Evidence strengthLow
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 21 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 13 of the 62 points we could judge it on, which is 21 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (Research Square) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “app/ps1”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 13 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 13 of the 62 points we could judge it on is 21 out of 100. |
| Total | 21 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Mei, X., Cui, W., Zhao, Z., Wang, M., Lin, Y., Xu, J., et al. (2026). Integrated Proteomic and Phosphoproteomic Profiling Reveals Distinct Disease- and Age-Related Molecular Alterations in the Retina and Hippocampus of APP/PS1/MAPT Mice. Research Square. https://doi.org/10.21203/rs.3.rs-10181171/v1
Vancouver
Mei X, Cui W, Zhao Z, Wang M, Lin Y, Xu J, et al. Integrated Proteomic and Phosphoproteomic Profiling Reveals Distinct Disease- and Age-Related Molecular Alterations in the Retina and Hippocampus of APP/PS1/MAPT Mice. Research Square. 2026. doi:10.21203/rs.3.rs-10181171/v1.
BibTeX
@article{mei2026-b38d440a,
author = {Mei, X. and Cui, W. and Zhao, Z. and Wang, M. and Lin, Y. and Xu, J. and Qiu, C. and Wu, T.},
title = {{Integrated Proteomic and Phosphoproteomic Profiling Reveals Distinct Disease- and Age-Related Molecular Alterations in the Retina and Hippocampus of APP/PS1/MAPT Mice}},
journal = {Research Square},
year = {2026},
doi = {10.21203/rs.3.rs-10181171/v1},
url = {https://doi.org/10.21203/rs.3.rs-10181171/v1}
}
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