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Association of neighborhood socioeconomic disadvantage and cognitive impairment
Maria E. Vassilaki, Jeremiah A. Aakre, Anna M. Castillo, Alanna M. Chamberlain, Patrick M. Wilson, Walter K. Kremers, Michelle M. Mielke, Yonas E. Geda et al.. Alzheimer s & Dementia, 2022-06-06
Topic: Risk, prevention and care in population studies
In cognitively unimpaired (CU) adults at baseline, the risk for progression to dementia increased for every decile increase in the ADI state ranking (hazard ratio = 1.06, 95% confidence interval (1.01-1.11), P = .01). Higher ADI values were associated with subtly faster cognitive decline. In older CU adults, higher baseline neighborhood socioeconomic deprivation levels were associated with progression to dementia and slightly faster cognitive decline. HIGHLIGHTS: The study used area deprivation index, a composite freely available neighborhood deprivation measure. Higher levels of neighborhood deprivation were associated with greater mild cognitive impairment odds. Higher neighborhood deprivation levels were associated with higher dementia risk.
Key findings
- In cognitively unimpaired (CU) adults at baseline, the risk for progression to dementia increased for every decile increase in the ADI state ranking (hazard ratio = 1.06, 95% confidence interval (1.01-1.11), P = .01).
- Higher ADI values were associated with subtly faster cognitive decline.
- In older CU adults, higher baseline neighborhood socioeconomic deprivation levels were associated with progression to dementia and slightly faster cognitive decline.
- HIGHLIGHTS: The study used area deprivation index, a composite freely available neighborhood deprivation measure.
- Higher levels of neighborhood deprivation were associated with greater mild cognitive impairment odds.
Why it matters
This study found that in cognitively unimpaired older adults, higher baseline neighborhood socioeconomic deprivation was associated with progression to dementia and slightly faster cognitive decline. It also found that higher levels of neighborhood deprivation were associated with greater mild cognitive impairment odds and higher dementia risk.
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Study details
- Participants4,699
- Evidence strengthLow
How this study scored 57/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 4,699 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 68 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.3 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 6.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 19 other studies in this library |
| Still being cited | 3 / 4 | Cited 57 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Ronald Carl Petersen: h-index 209 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35666244) |
| Free to read | 2 / 2 | Free to read |
| Total | 57 / 100 | — |
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Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Vassilaki, M. E., Aakre, J. A., Castillo, A. M., Chamberlain, A. M., Wilson, P. M., Kremers, W. K., et al. (2022). Association of neighborhood socioeconomic disadvantage and cognitive impairment. Alzheimer s & Dementia. https://doi.org/10.1002/alz.12702
Vancouver
Vassilaki ME, Aakre JA, Castillo AM, Chamberlain AM, Wilson PM, Kremers WK, et al. Association of neighborhood socioeconomic disadvantage and cognitive impairment. Alzheimer s & Dementia. 2022. doi:10.1002/alz.12702. PMID: 35666244.
BibTeX
@article{vassilaki2022-35666244,
author = {Vassilaki, Maria E. and Aakre, Jeremiah A. and Castillo, Anna M. and Chamberlain, Alanna M. and Wilson, Patrick M. and Kremers, Walter K. and Mielke, Michelle M. and Geda, Yonas E. and others},
title = {{Association of neighborhood socioeconomic disadvantage and cognitive impairment}},
journal = {Alzheimer s \& Dementia},
year = {2022},
doi = {10.1002/alz.12702},
pmid = {35666244},
url = {https://doi.org/10.1002/alz.12702}
}
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