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LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions
Zhao P, Xu Y, Jiang LL, Fan X, Ku Z, Li L, Liu X, Deng M et al.. Molecular neurodegeneration, 2022-06-18
Topic: Brain proteins, microglia and lab models
Background Microglia plays crucial roles in Alzheimer's disease (AD) development. Triggering receptor expressed on myeloid cells 2 (TREM2) in association with DAP12 mediates signaling affecting microglia function. Here we study the negative regulation of TREM2 functions by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2), an inhibitory receptor bearing ITIM motifs.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhao, P., Xu, Y., Jiang, L. L., Fan, X., Ku, Z., Li, L., et al. (2022). LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Molecular neurodegeneration. https://doi.org/10.1186/s13024-022-00550-y
Vancouver
Zhao P, Xu Y, Jiang LL, Fan X, Ku Z, Li L, et al. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Molecular neurodegeneration. 2022. doi:10.1186/s13024-022-00550-y. PMID: 35717259.
BibTeX
@article{zhao2022-35717259,
author = {Zhao, P. and Xu, Y. and Jiang, L. L. and Fan, X. and Ku, Z. and Li, L. and Liu, X. and Deng, M. and others},
title = {{LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions}},
journal = {Molecular neurodegeneration},
year = {2022},
doi = {10.1186/s13024-022-00550-y},
pmid = {35717259},
url = {https://doi.org/10.1186/s13024-022-00550-y}
}
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Key findings
- Triggering receptor expressed on myeloid cells 2 (TREM2) in association with DAP12 mediates signaling affecting microglia function.
- Here we study the negative regulation of TREM2 functions by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2), an inhibitory receptor bearing ITIM motifs.
- Methods To specifically interrogate LILRB2-ligand (oAβ and PS) interactions and microglia functions, we generated potent antagonistic LILRB2 antibodies with sub-nanomolar level activities.
- The biological effects of LILRB2 antagonist antibody (Ab29) were studied in human induced pluripotent stem cell (iPSC)-derived microglia (hMGLs) for migration, oAβ phagocytosis, and upregulation of inflammatory cytokines.
Why it matters
This study found that LILRB2 can negatively regulate TREM2 signaling and suppress microglia functions, and generated antagonistic LILRB2 antibodies to study these interactions. These are laboratory findings about microglial signaling and do not yet show a treatment, cure or prevention for Alzheimer's disease.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Molecular neurodegeneration) |
| Journal's citation record | 2 / 4 | Molecular Neurodegeneration: journal h-index 164 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 53 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.8 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 2 / 6 | Cited 2.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 43 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Zhiqiang An: h-index 64 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The University of Texas Southwestern Medical Center: institution h-index 1,356 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35717259) |
| Free to read | 2 / 2 | Free to read |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13024-022-00550-y
- PubMed: 35717259
- Original source →
- Free full text: Molecular Neurodegeneration →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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