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TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology
Chao-Ji Yu, Meng Wang, Rui-Yang Li, Tao Wei, Han-Chen Yang, Yun-Si Yin, Ying-Xin Mi, Qi Qin et al.. Molecular neurobiology, 2022-11-01
Topic: Inflammation, microglia and astrocytes
Synapses are bridges for information transmission in the central nervous system (CNS), and synaptic plasticity is fundamental for the normal function of synapses, contributing substantially to learning and memory. Numerous studies have proven that microglia can participate in the occurrence and progression of neurodegenerative diseases (NDDs), such as Alzheimer's disease (AD), by regulating synaptic plasticity. In this review, we summarize the main characteristics of synapses and synaptic plasticity under physiological and pathological conditions. We elaborate the origin and development of microglia and the two well-known microglial signaling pathways that regulate synaptic plasticity. We also highlight the unique role of triggering receptor expressed on myeloid cells 2 (TREM2) in microglia-mediated regulation of synaptic plasticity and its relationship with AD. Finally, we propose four possible ways in which TREM2 is involved in regulating synaptic plasticity. This review will help researchers understand how NDDs develop from the perspective of synaptic plasticity.
Key findings
- In this review, we summarize the main characteristics of synapses and synaptic plasticity under physiological and pathological conditions.
- We elaborate the origin and development of microglia and the two well-known microglial signaling pathways that regulate synaptic plasticity.
- We also highlight the unique role of triggering receptor expressed on myeloid cells 2 (TREM2) in microglia-mediated regulation of synaptic plasticity and its relationship with AD.
- Finally, we propose four possible ways in which TREM2 is involved in regulating synaptic plasticity.
- This review will help researchers understand how NDDs develop from the perspective of synaptic plasticity.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Molecular neurobiology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36318443) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Yu, C.-J., Wang, M., Li, R.-Y., Wei, T., Yang, H.-C., Yin, Y.-S., et al. (2023). TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology. Molecular neurobiology. https://doi.org/10.1007/s12035-022-03100-1
Vancouver
Yu C.-J, Wang M, Li R.-Y, Wei T, Yang H.-C, Yin Y.-S, et al. TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology. Molecular neurobiology. 2023. doi:10.1007/s12035-022-03100-1. PMID: 36318443.
BibTeX
@article{yu2023-36318443,
author = {Yu, Chao-Ji and Wang, Meng and Li, Rui-Yang and Wei, Tao and Yang, Han-Chen and Yin, Yun-Si and Mi, Ying-Xin and Qin, Qi and others},
title = {{TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology}},
journal = {Molecular neurobiology},
year = {2023},
doi = {10.1007/s12035-022-03100-1},
pmid = {36318443},
url = {https://doi.org/10.1007/s12035-022-03100-1}
}
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