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TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma
Tan J, Fan W, Liu T, Zhu B, Liu Y, Wang S, Wu J, Liu J et al.. Journal of hepatology, 2023-03-06
Topic: Brain proteins, microglia and lab models
Background & aims The immune landscape of hepatocellular carcinoma (HCC) following transarterial chemoembolisation (TACE) remains to be clarified. This study aimed to characterise the immune landscape following TACE and the underlying mechanism of HCC progression. Methods Tumour samples from five patients with treatment-naive HCC and five patients who received TACE therapy were collected and subjected to single-cell RNA sequencing.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Tan, J., Fan, W., Liu, T., Zhu, B., Liu, Y., Wang, S., et al. (2023). TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma. Journal of hepatology. https://doi.org/10.1016/j.jhep.2023.02.032
Vancouver
Tan J, Fan W, Liu T, Zhu B, Liu Y, Wang S, et al. TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma. Journal of hepatology. 2023. doi:10.1016/j.jhep.2023.02.032. PMID: 36889359.
BibTeX
@article{tan2023-36889359,
author = {Tan, J. and Fan, W. and Liu, T. and Zhu, B. and Liu, Y. and Wang, S. and Wu, J. and Liu, J. and others},
title = {{TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma}},
journal = {Journal of hepatology},
year = {2023},
doi = {10.1016/j.jhep.2023.02.032},
pmid = {36889359},
url = {https://doi.org/10.1016/j.jhep.2023.02.032}
}
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Key findings
- This study aimed to characterise the immune landscape following TACE and the underlying mechanism of HCC progression.
- Methods Tumour samples from five patients with treatment-naive HCC and five patients who received TACE therapy were collected and subjected to single-cell RNA sequencing.
- Another 22 paired samples were validated using immunofluorescence staining and flow cytometry.
- To clarify the underlying mechanisms, in vitro co-culture experiments and two types of TREM2-KO/WT mouse models, namely, an HCC cell orthotopic injection model and a spontaneous HCC model, were used.
Why it matters
This study is about liver cancer treated with transarterial chemoembolisation, not Alzheimer's disease, so it provides no direct information about treating, curing or preventing Alzheimer's. Its findings on TREM2-positive macrophages and CD8-positive T cells come from human liver tumour samples and mouse models of liver cancer.
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Study details
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of hepatology) |
| Journal's citation record | 3 / 4 | Journal of Hepatology: journal h-index 382 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 242 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 48.4 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 5 / 6 | Cited 21.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 4 / 4 | Cited 234 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Jiaping Li: h-index 41 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Sun Yat-sen University: institution h-index 851 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36889359) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
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