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Caregiver Burden and Quality of Life Across Alzheimer's Disease Severity Stages
Valérie J van Hezik-Wester, Ron L H Handels, Claire A G Wolfs, Tim A Kanters. Alzheimer disease and associated disorders, 2023-05-08
Topic: Health services, long-term care and technology
One hundred two caregivers participated. PwADs received, on average, 26 hours of informal care per week. Informal care costs were higher for community-dwelling PwADs compared with institutionalized PwADs (€480 and €278, respectively). On the EQ-5D-5L, caregivers scored on average 0.797, reflecting a utility decrement of 0.065 compared with an age-matched population. Proxy-rated utility scores for PwADs decreased with increasing disease severity (0.455, 0.314, and 0.212 for mild, moderate, and severe AD, respectively). Institutionalised PwADs had lower utility scores than community-dwelling PwADs (0.590 vs. 0.421). There was no difference in informal care time, societal costs, CarerQol scores, and caregiver EQ-5D-5L scores between disease severities. The burden of AD extends to caregivers in terms of HRQoL and time investment, regardless of the disease severity of the target population. These impacts should be incorporated into the evaluation of new AD interventions.
Key findings
- PwADs received, on average, 26 hours of informal care per week.
- Informal care costs were higher for community-dwelling PwADs compared with institutionalized PwADs (€480 and €278, respectively).
- On the EQ-5D-5L, caregivers scored on average 0.797, reflecting a utility decrement of 0.065 compared with an age-matched population.
- Proxy-rated utility scores for PwADs decreased with increasing disease severity (0.455, 0.314, and 0.212 for mild, moderate, and severe AD, respectively).
- Institutionalised PwADs had lower utility scores than community-dwelling PwADs (0.590 vs. 0.421).
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer disease and associated disorders) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37253123) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
van Hezik-Wester, V. J., Handels, R. L. H., Wolfs, C. A. G., & Kanters, T. A. (2023). Caregiver Burden and Quality of Life Across Alzheimer's Disease Severity Stages. Alzheimer disease and associated disorders. https://doi.org/10.1097/wad.0000000000000558
Vancouver
van Hezik-Wester VJ, Handels RLH, Wolfs CAG, Kanters TA. Caregiver Burden and Quality of Life Across Alzheimer's Disease Severity Stages. Alzheimer disease and associated disorders. 2023. doi:10.1097/wad.0000000000000558. PMID: 37253123.
BibTeX
@article{vanhezikwester2023-37253123,
author = {van Hezik-Wester, Valérie J and Handels, Ron L H and Wolfs, Claire A G and Kanters, Tim A},
title = {{Caregiver Burden and Quality of Life Across Alzheimer's Disease Severity Stages}},
journal = {Alzheimer disease and associated disorders},
year = {2023},
doi = {10.1097/wad.0000000000000558},
pmid = {37253123},
url = {https://doi.org/10.1097/wad.0000000000000558}
}
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