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Cluster‐Derived Psychosocial Phenotypes, Cognitive Outcomes, and AD Plasma Biomarkers of Black and Hispanic/Latino Older Adults Enrolled in HABS‐HD
Alexandra L. Clark, Kelsey R. Thomas, Andreana P. Haley, Audrey Duarte. Alzheimer s & Dementia, 2023-12-01
Topic: Risk, prevention and care in population studies
Abstract Background Although Black and Hispanic/Latino older adults are at increased risk for Alzheimer’s disease (AD), there is considerable within‐group heterogeneity in psychosocial factors of risk and resiliency amongst these community members. Result The cluster analysis identified 3 distinct groups: Group 1 was low resource/high distress (n = 215); Group 2 was high resource/low distress (n = 248); and Group 3 was low resource/low distress (n = 353; Figure 1). Results revealed significant group differences in education and the proportion of women and Black adults across the groups (see Table 1). ANCOVAs revealed significant group differences in subjective memory concerns, executive functioning composite, and plasma AD biomarkers; Group 1 consistently displayed poorer cognitive outcomes and more severe AD biomarker patterns relative to Groups 2 and 3, but there no differences in outcomes between Groups 2 and 3. Group 1 represents individuals with low resources and high levels of distress that may be at increased risk for poor outcomes in late life.
Key findings
- Abstract Background Although Black and Hispanic/Latino older adults are at increased risk for Alzheimer’s disease (AD), there is considerable within‐group heterogeneity in psychosocial factors of risk and resiliency amongst these community members.
- Result The cluster analysis identified 3 distinct groups: Group 1 was low resource/high distress (n = 215); Group 2 was high resource/low distress (n = 248); and Group 3 was low resource/low distress (n = 353; Figure 1).
- Results revealed significant group differences in education and the proportion of women and Black adults across the groups (see Table 1).
- ANCOVAs revealed significant group differences in subjective memory concerns, executive functioning composite, and plasma AD biomarkers; Group 1 consistently displayed poorer cognitive outcomes and more severe AD biomarker patterns relative to Groups 2 and 3, but there no differences in outcomes between Groups 2 and 3.
- Group 1 represents individuals with low resources and high levels of distress that may be at increased risk for poor outcomes in late life.
Why it matters
Black and Hispanic/Latino older adults fell into three psychosocial groups, and the group with low resources and high distress had poorer cognitive outcomes and more severe Alzheimer's blood biomarker patterns than the other two groups. There were no outcome differences between the high-resource/low-distress and low-resource/low-distress groups.
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Study details
- Study designlongitudinal study
- Participants215
- Effect size95.3%
- Evidence strengthModerate
How this study scored 47/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 215 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Audrey Duarte: h-index 37 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California San Diego: institution h-index 1,852 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Total | 47 / 100 | — |
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Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Clark, A. L., Thomas, K. R., Haley, A. P., & Duarte, A. (2023). Cluster‐Derived Psychosocial Phenotypes, Cognitive Outcomes, and AD Plasma Biomarkers of Black and Hispanic/Latino Older Adults Enrolled in HABS‐HD. Alzheimer s & Dementia. https://doi.org/10.1002/alz.083049
Vancouver
Clark AL, Thomas KR, Haley AP, Duarte A. Cluster‐Derived Psychosocial Phenotypes, Cognitive Outcomes, and AD Plasma Biomarkers of Black and Hispanic/Latino Older Adults Enrolled in HABS‐HD. Alzheimer s & Dementia. 2023. doi:10.1002/alz.083049.
BibTeX
@article{clark2023-27d4bca8,
author = {Clark, Alexandra L. and Thomas, Kelsey R. and Haley, Andreana P. and Duarte, Audrey},
title = {{Cluster‐Derived Psychosocial Phenotypes, Cognitive Outcomes, and AD Plasma Biomarkers of Black and Hispanic/Latino Older Adults Enrolled in HABS‐HD}},
journal = {Alzheimer s \& Dementia},
year = {2023},
doi = {10.1002/alz.083049},
url = {https://doi.org/10.1002/alz.083049}
}
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