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The Association Between Exposure to Air Pollution and Dementia Incidence: The Modifying Effect of Smoking
Guo-Chong Chen, Daniel Nyarko Hukportie, Zhongxiao Wan, Fu-Rong Li, Xian-Bo Wu. The journals of gerontology. Series A, Biological sciences and medical sciences, 2023-12-01
Topic: Air pollution and environmental exposures
During a median 11.7 years follow-up, 5 905 incident cases of all-cause dementia were identified. With the exception of PM2.5-10, all other air pollutants were separately associated with a higher risk of all-cause dementia (all p-trend < .001) with generally similar associations for dementia subtypes. An increasing air pollution score was associated with higher risks of all-cause as well as individual dementia outcomes, with adjusted HRs (95% CI) of 1.27 (1.18, 1.37) for all-cause dementia, 1.27 (1.14, 1.43) for Alzheimer's disease, and 1.35 (1.16, 1.57) for vascular dementia when comparing the highest with the lowest quartile of the score (all p-trend < .001). These associations of air pollution score with dementia and its subtypes were observed among never and former smokers but not among current smokers (all p-interaction < .030). Air pollution was associated with a higher risk of dementia among nonsmokers but not current smokers. Additional studies are required to confirm our findings and to explore the potential mechanisms underlying the possible effect modification by smoking status.
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APA 7th
Chen, G.-C., Hukportie, D. N., Wan, Z., Li, F.-R., & Wu, X.-B. (2023). The Association Between Exposure to Air Pollution and Dementia Incidence: The Modifying Effect of Smoking. The journals of gerontology. Series A, Biological sciences and medical sciences. https://doi.org/10.1093/gerona/glac228
Vancouver
Chen G.-C, Hukportie DN, Wan Z, Li F.-R, Wu X.-B. The Association Between Exposure to Air Pollution and Dementia Incidence: The Modifying Effect of Smoking. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023. doi:10.1093/gerona/glac228. PMID: 36373950.
BibTeX
@article{chen2023-36373950,
author = {Chen, Guo-Chong and Hukportie, Daniel Nyarko and Wan, Zhongxiao and Li, Fu-Rong and Wu, Xian-Bo},
title = {{The Association Between Exposure to Air Pollution and Dementia Incidence: The Modifying Effect of Smoking}},
journal = {The journals of gerontology. Series A, Biological sciences and medical sciences},
year = {2023},
doi = {10.1093/gerona/glac228},
pmid = {36373950},
url = {https://doi.org/10.1093/gerona/glac228}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- During a median 11.7 years follow-up, 5 905 incident cases of all-cause dementia were identified.
- With the exception of PM2.5-10, all other air pollutants were separately associated with a higher risk of all-cause dementia (all p-trend < .001) with generally similar associations for dementia subtypes.
- An increasing air pollution score was associated with higher risks of all-cause as well as individual dementia outcomes, with adjusted HRs (95% CI) of 1.27 (1.18, 1.37) for all-cause dementia, 1.27 (1.14, 1.43) for Alzheimer's disease, and 1.35 (1.16, 1.57) for vascular dementia when comparing the highest with the lowest quartile of the score (all p-trend < .001).
- These associations of air pollution score with dementia and its subtypes were observed among never and former smokers but not among current smokers (all p-interaction < .030).
- Air pollution was associated with a higher risk of dementia among nonsmokers but not current smokers.
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Study details
- Participants459
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The journals of gerontology. Series A, Biological sciences and medical sciences) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 459 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36373950) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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