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Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation
Takeru Nagayama, Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Takashi Saito, Takaomi C Saido, Shuji Wakatsuki, Toshiyuki Araki. Neuroscience research, 2024-03-19
Topic: Disease mechanisms in lab and animal studies
Sleep apnea is regarded as an important risk factor in the pathogenesis of Alzheimer disease (AD). Chronic intermittent hypoxia treatment (IHT) given during the sleep period of the circadian cycle in experimental animals is a well-established sleep apnea model. Here we report that transient IHT for 4 days on AD model mice causes Aβ overproduction 2 months after IHT presumably via upregulation of synaptic BACE1, side-by-side with tau hyperphosphorylation. These results suggest that even transient IHT may be sufficient to cause long-lasting changes in the molecules measured as AD biomarkers in the brain.
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APA 7th
Nagayama, T., Yagishita, S., Shibata, M., Furuno, A., Saito, T., Saido, T. C., et al. (2024). Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation. Neuroscience research. https://doi.org/10.1016/j.neures.2024.03.003
Vancouver
Nagayama T, Yagishita S, Shibata M, Furuno A, Saito T, Saido TC, et al. Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation. Neuroscience research. 2024. doi:10.1016/j.neures.2024.03.003. PMID: 38508957.
BibTeX
@article{nagayama2024-38508957,
author = {Nagayama, Takeru and Yagishita, Sosuke and Shibata, Megumi and Furuno, Akiko and Saito, Takashi and Saido, Takaomi C and Wakatsuki, Shuji and Araki, Toshiyuki},
title = {{Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation}},
journal = {Neuroscience research},
year = {2024},
doi = {10.1016/j.neures.2024.03.003},
pmid = {38508957},
url = {https://doi.org/10.1016/j.neures.2024.03.003}
}
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Key findings
- These results suggest that even transient IHT may be sufficient to cause long-lasting changes in the molecules measured as AD biomarkers in the brain.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuroscience research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38508957) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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