Home › Research › Risk factors
Cognitive reserve, cortisol, and Alzheimer's disease biomarkers: A memory clinic study
Manasa Shanta Yerramalla, Alexander Darin-Mattsson, Chinedu T Udeh-Momoh, Jasper Holleman, Ingemar Kåreholt, Malin Aspö, Göran Hagman, Miia Kivipelto et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024-06-04
Topic: Brain imaging, connectivity and assessment
Higher CRI scores were associated with better cognition. Adjusting for cortisol measures reduced the beneficial association of CRI on cognition. A higher CRI score was associated with better working memory in individuals with higher (favorable) cortisol AM/PM ratio, but not among individuals with low cortisol AM/PM ratio. No association was found between CRI and AD-related biomarkers. Physiological stress reduces the neurocognitive benefits of cognitive reserve among memory clinic patients. HIGHLIGHTS: Physiological stress may reduce the neurocognitive benefits accrued from cognitively stimulating and enriching life experiences (cognitive reserve [CR]) in memory clinic patients. Cortisol awakening response modified the relation between CR and P-tau181, a marker of Alzheimer's disease (AD). Effective stress management techniques for AD and related dementia prevention are warranted.
Key findings
- Higher CRI scores were associated with better cognition.
- Adjusting for cortisol measures reduced the beneficial association of CRI on cognition.
- A higher CRI score was associated with better working memory in individuals with higher (favorable) cortisol AM/PM ratio, but not among individuals with low cortisol AM/PM ratio.
- No association was found between CRI and AD-related biomarkers.
- Physiological stress reduces the neurocognitive benefits of cognitive reserve among memory clinic patients.
New to this subject? Start with our plain-English guide: Risk factors, ranked →
Study details
- Study designcross-sectional
- Evidence strengthModerate
How this study scored 57/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 32 of the 56 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38837661) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 32 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 32 of the 56 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Yerramalla, M. S., Darin-Mattsson, A., Udeh-Momoh, C. T., Holleman, J., Kåreholt, I., Aspö, M., et al. (2024). Cognitive reserve, cortisol, and Alzheimer's disease biomarkers: A memory clinic study. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.13866
Vancouver
Yerramalla MS, Darin-Mattsson A, Udeh-Momoh CT, Holleman J, Kåreholt I, Aspö M, et al. Cognitive reserve, cortisol, and Alzheimer's disease biomarkers: A memory clinic study. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. doi:10.1002/alz.13866. PMID: 38837661.
BibTeX
@article{yerramalla2024-38837661,
author = {Yerramalla, Manasa Shanta and Darin-Mattsson, Alexander and Udeh-Momoh, Chinedu T and Holleman, Jasper and Kåreholt, Ingemar and Aspö, Malin and Hagman, Göran and Kivipelto, Miia and others},
title = {{Cognitive reserve, cortisol, and Alzheimer's disease biomarkers: A memory clinic study}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2024},
doi = {10.1002/alz.13866},
pmid = {38837661},
url = {https://doi.org/10.1002/alz.13866}
}