Newest studies

A First-in-Class, Brain-Penetrant Small Molecule Inhibitor of the NOS1AP-Tau Interaction Rescues Tau Pathology In Vivo and Improves Cognition

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers bioRxiv

Key finding: A drug-resistant NOS1AP Y16A/F42A variant that retained tau binding but exhibited a 78-fold reduction in CAPTOR-1 affinity provides genetic evidence supporting an on-target mechanism. +4 more findings

• Biomarkers
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A Pipeline for ADNI Resting-State Functional MRI Processing and Quality Control

16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies Research Square

Key finding: Processed imaging sessions are matched to temporally aligned clinical assessments to produce an analysis-ready dataset. +4 more findings

• Brain Scans

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Cognitive and Renal Outcomes of Finerenone in Older Adults With Heart Failure With Preserved Ejection Fraction: A Real-World Cohort Study

16/100 ⚠ Preprint — not yet peer-reviewed How common it is Research Square

Key finding: In older adults with HFpEF, finerenone conferred renal benefit without a detectable short-term cognitive signal. +2 more findings

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Multilingualism and ageing: Cognitive and affective trajectories in the Australian Longitudinal Study of Ageing

16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment Research Square

Key finding: This study aimed to address these limitations by examining whether multilingual experience is associated with longitudinal ageing trajectories across objective and subjective measures spanning cognitive, affective, linguistic, and non-linguistic domains. +4 more findings

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Evaluating Large Language Model Diagnostic Classification in Neuropsychology

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools PsyArXiv

Key finding: Model-inferred and reference diagnoses showed exact agreement rates from 18.8% to 56.2% with poor to slight chance-corrected agreement (Cohen’s κ = −.178 to .196). +4 more findings

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Contribution of cerebrovascular lesions to neurodegeneration and cognitive decline

16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions medRxiv

Key finding: Vascular risk factors were associated with CSVD burden and progression, and WMH and PVS progression were further associated with cortical atrophy and cognitive decline, underscoring the interconnected contributions of vascular risk, CSVD, and neurodegeneration to cognitive aging and dementia risk. +4 more findings

• Risk Factors
• Brain Scans

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The protective effect of NGF mutant CHF6467 in SH SY5Y cells exposed to Aβ(1–42): a pharmacometabolomic approach

16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions bioRxiv

Key finding: Research shows NGF’s neuroprotective and regenerative effects on cholinergic neurons, with positive results in AD models and clinical studies. +2 more findings

• Brain Biology
• Prevention

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The microbial soy metabolite S-equol mitigates cadmium neurotoxicity in mice

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

Key finding: Cadmium is a pervasive toxic metal encountered through diet and tobacco smoke that has been associated with cognitive impairment and Alzheimer’s disease mortality, yet strategies to mitigate its neurotoxicity remain limited.

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Brief Communication: Frailty and Neurocognitive Impairment in Older People Living with HIV: A Cross-Sectional Study from Southeastern Brazil

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

Key finding: Mean age was 59.6 years, and 57.8% were male. +3 more findings

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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What Do Care Staff Know About Behavioural and Psychological Symptoms of Dementia? A Mixed- Methods Study in Long-Term Care

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

Key finding: Mean scores were 23.45/30 (78.2%) for general Alzheimer’s disease knowledge and 13.75/18 (76.4%) for BPSD knowledge; the scores were moderately correlated (ρ = .598, p < .001). +2 more findings

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Memory and executive functioning show differential associations with scam susceptibility in middle to older adulthood

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: Prior work has demonstrated a link between cognitive impairment and financial vulnerability. +4 more findings

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Circular Data Analysis for Spatial Omics

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: We conclude with practical recommendations and directions for future methodological development.

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Simulating the Effects of Gamma Oscillation Treatment on Selective Neurotransmitters Using The Virtual Brain and Complex Pathway Simulator

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square

Key finding: Alzheimer's Disease (AD), the most common neurodegenerative disease in the world, is caused by a variety of factors that lead to neuronal injury and an alteration in neurotransmitter production and release. +1 more finding

• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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When Is Amyloid Really Cleared? Substantial Discordance Between Centiloid Quantitation and Visual Reads of Amyloid PET after Amyloid-Targeting Therapy

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv

Key finding: : Treated patients were 74±7 years old; 57% were female, 59% were apolipoprotein E ε4 carriers, and 78% had mild cognitive impairment (22% mild dementia). +4 more findings

• Treatments
• Brain Scans

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Person-centred care in the early post-diagnostic phase of young-onset dementia: co-created insights from service users and professionals through participatory action research

16/100 ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE Research Square

Key finding: Realising PCC in YOD requires not only identifying individual needs and appropriate care components, but also ongoing alignment of changing needs, expectations, timing, and responsibilities across the care trajectory. +1 more finding

• Diagnosis

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Closed-head injury produces a delayed, region-specific defect in glucose-carbon routing at the pyruvate branchpoint in APP/PS1 KI mice

16/100 ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE bioRxiv

Key finding: Traumatic brain injury (TBI) is a risk factor for Alzheimer’s disease (AD), and both conditions are associated with impaired glucose metabolism and mitochondrial dysfunction. +1 more finding

• Risk Factors
• Brain Biology
• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Cross-Dataset Reanalysis of Mouse Alzheimer Disease Single-Cell RNA-Sequencing Data Reveals a Reproducible Innate Immune Activation Signature

16/100 ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics bioRxiv

Key finding: Pseudobulk differential expression, performed on 32 samples (16 AD, 16 Control) from five of the six datasets, identified 301 significant genes (FDR-adjusted p < 0.05) out of 20,629 tested, of which 290 (96.3%) were upregulated and 11 (3.7%) downregulated in AD. +2 more findings

• Brain Biology
• Genetics

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Sex differences in genetic liability to modifiable Alzheimer’s disease risk factors

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: Educational attainment and physical activity PRSs were associated with AD in both sexes. +4 more findings

• Risk Factors
• Biomarkers
• Genetics

Scored 58 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Blood Biomarkers of Alzheimer’s Disease Neuropathology, Cognition, and Response to a Multidomain Lifestyle Intervention: Secondary analysis of the FINGER Randomized Controlled Dementia Risk Reduction Trial

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: Here, we analyzed core AD plasma biomarkers (Aβ, p-tau181, p-tau217, p-tau231, NFL, GFAP) in the two-year FINGER randomized controlled multidomain lifestyle trial, which demonstrated cognitive efficacy in an at-risk older general population (N=1260). +4 more findings

• Biomarkers
• Clinical Trials
• Brain Biology

Scored 44 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Explainable machine learning identifies predictors for postural instability and cognitive impairment in early Parkinson’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment medRxiv

Key finding: We found comparable predictive performances of EBM models using a minimal clinico-demographic dataset compared to an extended multimodal dataset including volumetric brain imaging and fluid biomarkers.

• Early Stage
• Other Dementias
• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Imputation-Based Harmonization Mitigates Site Effects Without Data Leakage in Machine Learning Studies

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools bioRxiv

Key finding: Neuroimaging studies that pool data across clinical sites often suffer from site effects — variability in imaging measures that arises from technical heterogeneity across sites as opposed to true biological signal. +4 more findings

• Digital Tools

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Plasma eMTBR-tau as a robust biomarker for Alzheimer’s disease tangle pathology up to 10 years before death

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology medRxiv

Key finding: Here, we show that a blood-based immunoassay for an endogenously-cleaved “eMTBR-tau” fragment of tau protein is strongly associated with autopsy-diagnosed Alzheimer neuropathologic change (ADNC) and predominantly reflects the burden and anatomical progression of tangle pathology but not amyloid plaque load despite being most elevated in amyloid-positive symptomatic individuals. +3 more findings

• Biomarkers
• Brain Biology

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Multi-Target Neuroprotection by Syzygium aromaticum Ethyl Acetate Fraction Against Mercuric Chloride-Induced Hippocampal Toxicity: Insights from Network Pharmacology, Molecular Docking, and In Vivo Evaluation

45/100 ✓ Peer-reviewed Vascular contributions F1000Res

Key finding: Network pharmacology integrating SwissTargetPrediction, TargetNet, GeneCards, and the Therapeutic Target Database revealed 16 overlapping dementia-associated targets, with NFKB1 emerging alongside other genes as the principal hub governing nuclear receptor signalling, oxidative stress, and neuroinflammation pathways.

• Brain Biology

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Magnetic Field–Enhanced Docosahexaenoic Acid Delivery for Acetylcholine Restoration in Alzheimer’s Disease: an In Silico Study

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk bioRxiv

Key finding: Co-evolution analysis reveals the mechanism: by the end of a 2.0 s window the field elevates DHA 7.39-fold relative to baseline, driving ACh to 133.7% of threshold versus only 18.1% without the field. +1 more finding

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Adaptive Memory and Metacognition in Older Adulthood: A Path Towards Successful Aging

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors PsyArXiv

Key finding: Overall, leveraging older adults’ metacognitive abilities and enhanced motivation through targeted interventions may offer a promising approach to promoting successful aging among an increasingly growing aging population.

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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