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Revised Criteria for Diagnosis and Staging of Alzheimer's Disease: Alzheimer's Association Workgroup
Clifford R. Jack Jr., J. Scott Andrews, Thomas G. Beach, Teresa Burracchio, Billy Dunn, Ana Graf, Oskar Hansson, Carole Ho, William Jagust, Eric McDade, Jose Luis Molinuevo, Ozioma Okonkwo, Luca Pani, Michael Rafii, Philip Scheltens, Eric Siemers, Heather Snyder, Reisa Sperling, Charlotte E. Teunissen, Maria Carrillo, et al.. Alzheimer's & Dementia, 2024-06-27
Topic: Amyloid, tau and blood-test diagnosis
This Alzheimer's Association workgroup paper proposes a major update to how Alzheimer's disease is diagnosed: it defines the disease by biological markers (amyloid plaques and tau tangles detected via blood, CSF, or PET) rather than requiring clinical symptoms like memory loss to be present. It also introduces a numeric staging system tracking biomarker and clinical severity together.
Key findings
- Alzheimer's disease can now be diagnosed based on biomarker evidence alone, even before symptoms appear
- Introduces staging system integrating biological and clinical/functional severity
- Incorporates blood-based biomarkers into the diagnostic biomarker categories for the first time
Why it matters
Presymptomatic Alzheimer's disease can now be identified through blood biomarkers under revised diagnostic criteria, potentially enabling treatment to begin before cognitive symptoms appear. Blood-based biomarkers are incorporated into the diagnostic framework for the first time, providing an additional method for disease identification beyond cerebrospinal fluid and PET imaging.
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Study details
- Evidence strengthModerate
Limitations
This is an expert consensus/framework document, not an empirical study with its own participants or effect size.
How this study scored 42/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people, randomised / blinded and indexed in PubMed because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 26 of the 62 points we could judge it on, which is 42 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & Dementia) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 0 / 2 | No PubMed ID and no DOI — scores zero (not stated in the record — scored 0) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 26 / 62 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 26 of the 62 points we could judge it on is 42 out of 100. |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Jack, C. R., Jr., Andrews, J. S., Beach, T. G., Burracchio, T., Dunn, B., Graf, A., et al. (2024). Revised Criteria for Diagnosis and Staging of Alzheimer's Disease: Alzheimer's Association Workgroup. Alzheimer's & Dementia.
Vancouver
Jack CR Jr, Andrews JS, Beach TG, Burracchio T, Dunn B, Graf A, et al. Revised Criteria for Diagnosis and Staging of Alzheimer's Disease: Alzheimer's Association Workgroup. Alzheimer's & Dementia. 2024.
BibTeX
@article{jack2024-a1049d85,
author = {Jack, Jr., Clifford R. and Andrews, J. Scott and Beach, Thomas G. and Burracchio, Teresa and Dunn, Billy and Graf, Ana and Hansson, Oskar and Ho, Carole and Jagust, William and McDade, Eric and Molinuevo, Jose Luis and Okonkwo, Ozioma and Pani, Luca and Rafii, Michael and Scheltens, Philip and Siemers, Eric and Snyder, Heather and Sperling, Reisa and Teunissen, Charlotte E. and Carrillo, Maria and others},
title = {{Revised Criteria for Diagnosis and Staging of Alzheimer's Disease: Alzheimer's Association Workgroup}},
journal = {Alzheimer's \& Dementia},
year = {2024}
}