Role of Apolipoprotein E in Alzheimer's Disease Pathogenesis, Prognosis and Treatment
Allison B Reiss, Mary Housny, Shelly Gulkarov, Tahmina Hossain, Brandon Locke, Ankita Srivastava, Aaron Pinkhasov, Irving H Gomolin et al.. Discovery medicine, 2024-10
Topic: Genetics and APOE
Alzheimer's disease (AD) is an incurable and progressive neurodegenerative disease with increasing prevalence worldwide. Previous trials of anti-amyloid and anti-tau immunotherapy indicate that additional research needs to be conducted on other mechanisms to find curative or disease-modifying therapy. This review focuses on apolipoprotein E (ApoE), a critical protein in brain lipid metabolism that acts specifically in the clearance and transport of lipids and cholesterol. The ApoE4 allele confers substantial gene dose-dependent risk of developing AD and lowers the age of onset of AD, although the mechanisms of influence remain incompletely understood. The other isoforms bring different levels of AD risk. ApoE2 is protective while ApoE3 is the most common isoform and is considered neutral. An overview is presented of the latest information on the role of ApoE in AD pathogenesis with an emphasis on pathways that are involved in AD development and interactions with crucial processes in different cell types in the brain. Elucidating the key interactions of ApoE with multiple aspects of brain function can be useful for designing novel ApoE-targeted therapeutic approaches.
Key findings
- Previous trials of anti-amyloid and anti-tau immunotherapy indicate that additional research needs to be conducted on other mechanisms to find curative or disease-modifying therapy.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Discovery medicine) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39463215) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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APA 7th
Reiss, A. B., Housny, M., Gulkarov, S., Hossain, T., Locke, B., Srivastava, A., et al. (2024). Role of Apolipoprotein E in Alzheimer's Disease Pathogenesis, Prognosis and Treatment. Discovery medicine. https://doi.org/10.24976/discov.med.202436189.179
Vancouver
Reiss AB, Housny M, Gulkarov S, Hossain T, Locke B, Srivastava A, et al. Role of Apolipoprotein E in Alzheimer's Disease Pathogenesis, Prognosis and Treatment. Discovery medicine. 2024. doi:10.24976/discov.med.202436189.179. PMID: 39463215.
BibTeX
@article{reiss2024-39463215,
author = {Reiss, Allison B and Housny, Mary and Gulkarov, Shelly and Hossain, Tahmina and Locke, Brandon and Srivastava, Ankita and Pinkhasov, Aaron and Gomolin, Irving H and others},
title = {{Role of Apolipoprotein E in Alzheimer's Disease Pathogenesis, Prognosis and Treatment}},
journal = {Discovery medicine},
year = {2024},
doi = {10.24976/discov.med.202436189.179},
pmid = {39463215},
url = {https://doi.org/10.24976/discov.med.202436189.179}
}
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