Genetic variants for Alzheimer's disease and comorbid conditions
Minmin Pan, Dongbing Lai, Frederick Unverzagt, Liana Apostolova, Hugh C Hendrie, Andrew Saykin, Tatiana Foroud, Sujuan Gao. Journal of Alzheimer's disease : JAD, 2024-11-10
Topic: Genetics and APOE
Targeted analysis of 20 SNPs that were reported to be associated with ADRD revealed that six were significantly associated with dual-disease outcomes, specifically congestive heart failure and cancer. In addition, eight novel SNPs were identified for associations with both ADRD and a comorbid condition. Using a bivariate survival model approach, we identified genetic variants associated not only with ADRD, but also with comorbid conditions. Our utilization of dual-disease models represents a novel analytic strategy for uncovering shared genetic variants for multiple disease phenotypes.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Pan, M., Lai, D., Unverzagt, F., Apostolova, L., Hendrie, H. C., Saykin, A., et al. (2024). Genetic variants for Alzheimer's disease and comorbid conditions. Journal of Alzheimer's disease : JAD. https://doi.org/10.1177/13872877241289054
Vancouver
Pan M, Lai D, Unverzagt F, Apostolova L, Hendrie HC, Saykin A, et al. Genetic variants for Alzheimer's disease and comorbid conditions. Journal of Alzheimer's disease : JAD. 2024. doi:10.1177/13872877241289054. PMID: 39523637.
BibTeX
@article{pan2024-39523637,
author = {Pan, Minmin and Lai, Dongbing and Unverzagt, Frederick and Apostolova, Liana and Hendrie, Hugh C and Saykin, Andrew and Foroud, Tatiana and Gao, Sujuan},
title = {{Genetic variants for Alzheimer's disease and comorbid conditions}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2024},
doi = {10.1177/13872877241289054},
pmid = {39523637},
url = {https://doi.org/10.1177/13872877241289054}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Targeted analysis of 20 SNPs that were reported to be associated with ADRD revealed that six were significantly associated with dual-disease outcomes, specifically congestive heart failure and cancer.
- In addition, eight novel SNPs were identified for associations with both ADRD and a comorbid condition.
- Using a bivariate survival model approach, we identified genetic variants associated not only with ADRD, but also with comorbid conditions.
- Our utilization of dual-disease models represents a novel analytic strategy for uncovering shared genetic variants for multiple disease phenotypes.
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Study details
- Study designlongitudinal study
- Participants1,177
- Evidence strengthModerate
How this study scored 70/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 39 of the 56 points we could judge it on, which is 70 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,177 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39523637) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 39 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 39 of the 56 points we could judge it on is 70 out of 100. |
| Total | 70 / 100 | — |
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