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44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Mild cognitive impairment

Topic: Amyloid, tau and blood-test diagnosis

The left inferior parietal lobule (IPL)_6_5 (rostroventral area 39) showed the best ability to discriminate between patients with AD and those with CN (AUC = 0.688). The model consisting of the left IPL_6_4 (caudal area 40) and bilateral IPL_6_5 showed the best combination for predicting the CN progression to MCI. The left IPL_6_1 (caudal area 39) showed the best predictive power in predicting the progression of MCI to AD. Certain subregions of the volume correlated with cognitive scales. Subregions of the angular gyrus are essential in the early onset and subsequent development of AD, and early detection of the volume of these regions may be useful in identifying the tendency to develop the disease and its treatment.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Fang Gen, L. U., Ma, Q., Shi, C., & Yue, W. (2025). Changes in the Parietal Lobe Subregion Volume at Various Stages of Alzheimer’s Disease and the Role in Cognitively Normal and Mild Cognitive Impairment Conversion. Journal of Integrative Neuroscience. https://doi.org/10.31083/jin25991

Vancouver

Fang Gen LU, Ma Q, Shi C, Yue W. Changes in the Parietal Lobe Subregion Volume at Various Stages of Alzheimer’s Disease and the Role in Cognitively Normal and Mild Cognitive Impairment Conversion. Journal of Integrative Neuroscience. 2025. doi:10.31083/jin25991. PMID: 39862009.

BibTeX

@article{fanggen2025-39862009,
  author  = {Fang Gen, L. U. and Ma, Qing and Shi, Cailing and Yue, Wenjun},
  title   = {{Changes in the Parietal Lobe Subregion Volume at Various Stages of Alzheimer’s Disease and the Role in Cognitively Normal and Mild Cognitive Impairment Conversion}},
  journal = {Journal of Integrative Neuroscience},
  year    = {2025},
  doi     = {10.31083/jin25991},
  pmid    = {39862009},
  url     = {https://doi.org/10.31083/jin25991}
}

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Key findings

The left inferior parietal lobule (IPL)_6_5 (rostroventral area 39) showed the best ability to discriminate between patients with AD and those with CN (AUC = 0.688).
The model consisting of the left IPL_6_4 (caudal area 40) and bilateral IPL_6_5 showed the best combination for predicting the CN progression to MCI.
The left IPL_6_1 (caudal area 39) showed the best predictive power in predicting the progression of MCI to AD.
Certain subregions of the volume correlated with cognitive scales.
Subregions of the angular gyrus are essential in the early onset and subsequent development of AD, and early detection of the volume of these regions may be useful in identifying the tendency to develop the disease and its treatment.

Why it matters

This study found that specific subregions of the parietal lobe, particularly the angular gyrus, could help discriminate between Alzheimer's disease and normal cognition and predict progression from normal cognition to MCI and from MCI to Alzheimer's disease. The authors suggest early detection of volume changes in these regions may be useful in identifying disease tendency and its treatment, but no treatment was tested.

Study details

Participants662
Effect sizeAUC = 0.688
Evidence strengthLow

How this study scored 44/100

Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 42 of the 96 points we could judge it on, which is 44 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Integrative Neuroscience)
Journal's citation record	0 / 4	Journal of Integrative Neuroscience: journal h-index 53 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	662 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 5 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.7 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	0 / 3	Affiliated Hospital of North Sichuan Medical College: institution h-index 122 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39862009)
Free to read	2 / 2	Free to read
Points	42 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 42 of the 96 points we could judge it on is 44 out of 100.
Total	44 / 100	—

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