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Synergistic Nano-Architectures: How Date Seed Phytochemicals and Cellulose Matrices Template Silver Nanoparticles for Multifunctional Therapy
El-Sheikh M, Al-ruwaili R, Al-Maduh A, Al-Beladi S.. Research Square, 2026-09-07
Topic: Gut, metabolism and diet
This study reports the eco-friendly green synthesis of a multifunctional silver nanocomposite (DS-MC-Ag-nanocomposite) utilizing ethanolic extract of waste date seeds ( Phoenix dactylifera ) and methyl cellulose (MC) as dual reducing and stabilizing agents. Following optimization of reaction parameters (precursor concentrations, time, and temperature), the biogenic nanocomposite was characterized via UV-Vis, FTIR, TEM, SEM, EDX, XRD, and TGA. Biological evaluations demonstrated potent, wide-ranging therapeutic potential. The nanocomposite exhibited broad-spectrum antimicrobial activity against six clinical pathogens, showing highest sensitivity against A. baumannii (MIC = 100 µg/mL; MBC = 125 µg/mL). Strong antioxidant capacity was confirmed via DPPH assay IC₅₀ of 30.6 µg/mL. Crucially, antidiabetic assays revealed significant inhibition of carbohydrate-hydrolyzing enzymes, with IC₅₀ values of 112.4 µg/mL and 130.2 µg/mL against α-glucosidase and α-amylase, performing comparably to acarbose. Furthermore, neuroprotective evaluations demonstrated robust anti-Alzheimer potential, inhibiting acetylcholinesterase IC₅₀ of 189 µg/mL—closely matching donepezil (191.9 µg/mL), and showing anti-amyloidogenic activity against Aβ₁₋₄₂ fibrils (IC₅₀ = 221 µg/mL). Collectively, these findings validate the DS-MC-Ag-nanocomposite as a promising, biogenic, multifunctional nanotherapeutic platform synthesized via sustainable agricultural waste valorization for advanced biomedical applications.
Key findings
- Biological evaluations demonstrated potent, wide-ranging therapeutic potential.
- Crucially, antidiabetic assays revealed significant inhibition of carbohydrate-hydrolyzing enzymes, with IC₅₀ values of 112.4 µg/mL and 130.2 µg/mL against α-glucosidase and α-amylase, performing comparably to acarbose.
- Furthermore, neuroprotective evaluations demonstrated robust anti-Alzheimer potential, inhibiting acetylcholinesterase IC₅₀ of 189 µg/mL—closely matching donepezil (191.9 µg/mL), and showing anti-amyloidogenic activity against Aβ₁₋₄₂ fibrils (IC₅₀ = 221 µg/mL).
- Collectively, these findings validate the DS-MC-Ag-nanocomposite as a promising, biogenic, multifunctional nanotherapeutic platform synthesized via sustainable agricultural waste valorization for advanced biomedical applications.
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Study details
- Evidence strengthLow
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 21 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 13 of the 62 points we could judge it on, which is 21 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (Research Square) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 13 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 13 of the 62 points we could judge it on is 21 out of 100. |
| Total | 21 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
El-Sheikh, M., Al-ruwaili, R., Al-Maduh, A., & Al-Beladi, S. (2026). Synergistic Nano-Architectures: How Date Seed Phytochemicals and Cellulose Matrices Template Silver Nanoparticles for Multifunctional Therapy. Research Square. https://doi.org/10.21203/rs.3.rs-10617300/v1
Vancouver
El-Sheikh M, Al-ruwaili R, Al-Maduh A, Al-Beladi S. Synergistic Nano-Architectures: How Date Seed Phytochemicals and Cellulose Matrices Template Silver Nanoparticles for Multifunctional Therapy. Research Square. 2026. doi:10.21203/rs.3.rs-10617300/v1.
BibTeX
@article{elsheikh2026-9ea25c4a,
author = {El-Sheikh, M. and Al-ruwaili, R. and Al-Maduh, A. and Al-Beladi, S.},
title = {{Synergistic Nano-Architectures: How Date Seed Phytochemicals and Cellulose Matrices Template Silver Nanoparticles for Multifunctional Therapy}},
journal = {Research Square},
year = {2026},
doi = {10.21203/rs.3.rs-10617300/v1},
url = {https://doi.org/10.21203/rs.3.rs-10617300/v1}
}
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