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Perspective: Emerging challenges for a future ADNI
Zaven S. Khachaturian, María C. Carrillo, Ara S. Khachaturian. Alzheimer s & Dementia, 2025-02-01
Topic: Risk, prevention and care in population studies
In the last two decades, the Alzheimer's Disease Neuroimaging Initiative (ADNI) has significantly advanced our understanding, technologies, and methods for detecting and diagnosing Alzheimer's disease and related dementias. This perspective proposes repurposing ADNI to address emerging research and healthcare challenges. The focus would shift toward early detection of cognitive impairment, discovering new interventions, evaluating non-pharmacological treatments, adopting a public health approach, and enrolling a diverse international cohort. Key elements of this new model include emphasizing vascular-metabolic factors, leveraging biomarkers, and enhancing computational capabilities. By reimagining ADNI's mission and framework, the initiative may be better poised to tackle the evolving complexities of dementia research and improve patient outcomes through a more comprehensive, multidisciplinary approach. HIGHLIGHTS: ADNI should be repurposed for early detection and intervention in cognitive decline. This would emphasize vascular-metabolic factors and biomarkers in dementia research. It advocates for non-pharmacological evaluations and a public health approach. It promotes international cohort studies and enhanced computational capacity.
Key findings
- In the last two decades, the Alzheimer's Disease Neuroimaging Initiative (ADNI) has significantly advanced our understanding, technologies, and methods for detecting and diagnosing Alzheimer's disease and related dementias.
Why it matters
This perspective proposes repurposing the Alzheimer's Disease Neuroimaging Initiative toward early detection, new interventions, non-drug treatments, a public health approach, and a diverse international cohort. It is a proposal for future research direction, not a study of a treatment or cure.
Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 44/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Ara S. Khachaturian: h-index 36 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Alzheimer's Association: institution h-index 250 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40009569) |
| Free to read | 2 / 2 | Free to read |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Khachaturian, Z. S., Carrillo, M. C., & Khachaturian, A. S. (2025). Perspective: Emerging challenges for a future ADNI. Alzheimer s & Dementia. https://doi.org/10.1002/alz.14534
Vancouver
Khachaturian ZS, Carrillo MC, Khachaturian AS. Perspective: Emerging challenges for a future ADNI. Alzheimer s & Dementia. 2025. doi:10.1002/alz.14534. PMID: 40009569.
BibTeX
@article{khachaturian2025-40009569,
author = {Khachaturian, Zaven S. and Carrillo, María C. and Khachaturian, Ara S.},
title = {{Perspective: Emerging challenges for a future ADNI}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.14534},
pmid = {40009569},
url = {https://doi.org/10.1002/alz.14534}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.