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Network models of late life depression symptoms and cognitive impairments across time
Aoife Whiston, Maria Semkovska, Pauline Boland, Irene Cassidy, Alexandra Cremona, Sarah Dillon, Sara Hayes, Aine Kearns et al.. Aging & mental health, 2025-02-02
Topic: Brain imaging, connectivity and assessment
Across 3544 participants, ≥65 years of age, with no diagnosed dementia-related disorders, the depression symptom everything was an effort showed high expected influence across all time points. Across two time points, object naming and verbal fluency also showed high expected influence. Self-reported memory demonstrated high bridge centrality connecting depression symptom and cognitive impairment domains. Network centralities differed significantly across time points. For older adults, fatigue appears a key depression symptom. Cognitive impairment domains become more influential over time, and perceived memory loss links cognitive impairment to depression symptoms. Practical implications are discussed in relation to targeting depression symptoms and cognitive impairment domains.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Whiston, A., Semkovska, M., Boland, P., Cassidy, I., Cremona, A., Dillon, S., et al. (2025). Network models of late life depression symptoms and cognitive impairments across time. Aging & mental health. https://doi.org/10.1080/13607863.2025.2458075
Vancouver
Whiston A, Semkovska M, Boland P, Cassidy I, Cremona A, Dillon S, et al. Network models of late life depression symptoms and cognitive impairments across time. Aging & mental health. 2025. doi:10.1080/13607863.2025.2458075. PMID: 39894931.
BibTeX
@article{whiston2025-39894931,
author = {Whiston, Aoife and Semkovska, Maria and Boland, Pauline and Cassidy, Irene and Cremona, Alexandra and Dillon, Sarah and Hayes, Sara and Kearns, Aine and others},
title = {{Network models of late life depression symptoms and cognitive impairments across time}},
journal = {Aging \& mental health},
year = {2025},
doi = {10.1080/13607863.2025.2458075},
pmid = {39894931},
url = {https://doi.org/10.1080/13607863.2025.2458075}
}
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Key findings
- Across 3544 participants, ≥65 years of age, with no diagnosed dementia-related disorders, the depression symptom everything was an effort showed high expected influence across all time points.
- Across two time points, object naming and verbal fluency also showed high expected influence.
- Self-reported memory demonstrated high bridge centrality connecting depression symptom and cognitive impairment domains.
- Network centralities differed significantly across time points.
- For older adults, fatigue appears a key depression symptom.
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Study details
- Study designcross-sectional
- Participants3,544
- Evidence strengthModerate
How this study scored 64/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 36 of the 56 points we could judge it on, which is 64 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Aging & mental health) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 3,544 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39894931) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 36 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 36 of the 56 points we could judge it on is 64 out of 100. |
| Total | 64 / 100 | — |
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