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Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia
Christopher B. Morrow, Vidyulata J. Kamath, Bradford Clark Dickerson, Mark C. Eldaief, Neguine Rezaii, Bonnie Wong, Scott McGinnis, Ryan Darby et al.. Psychiatry and Clinical Neurosciences, 2025-03-13
Topic: Risk, prevention and care in population studies
NPS were highly prevalent (≥90%) in early and late bvFTD. Four NPS clusters were identified based on magnitude of factor loadings: affective, disinhibited, compulsive, and psychosis. Neuropsychiatric symptoms fluctuated across visits. In the affective cluster, depression showed the least visit-to-visit stability. In the disinhibited cluster, elation showed the least stability. Symptoms in the psychosis and compulsive clusters (hallucinations, delusions, obsessions/compulsions, and hyperorality) were largely stable, persisting from visit-to-visit in more than 50% of cases. Symptoms in the affective and disinhibited cluster were associated with the highest caregiver burden, while symptoms in the obsessive cluster were associated with the most functional impairment. NPS in bvFTD are frequent and cluster into four discrete groups. The fluctuating nature of some NPS in bvFTD suggests that they may not be reliable markers of disease progression or stage.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Morrow, C. B., Kamath, V. J., Dickerson, B. C., Eldaief, M. C., Rezaii, N., Wong, B., et al. (2025). Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia. Psychiatry and Clinical Neurosciences. https://doi.org/10.1111/pcn.13810
Vancouver
Morrow CB, Kamath VJ, Dickerson BC, Eldaief MC, Rezaii N, Wong B, et al. Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia. Psychiatry and Clinical Neurosciences. 2025. doi:10.1111/pcn.13810. PMID: 40079430.
BibTeX
@article{morrow2025-40079430,
author = {Morrow, Christopher B. and Kamath, Vidyulata J. and Dickerson, Bradford Clark and Eldaief, Mark C. and Rezaii, Neguine and Wong, Bonnie and McGinnis, Scott and Darby, Ryan and others},
title = {{Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia}},
journal = {Psychiatry and Clinical Neurosciences},
year = {2025},
doi = {10.1111/pcn.13810},
pmid = {40079430},
url = {https://doi.org/10.1111/pcn.13810}
}
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Key findings
- NPS were highly prevalent (≥90%) in early and late bvFTD.
- Four NPS clusters were identified based on magnitude of factor loadings: affective, disinhibited, compulsive, and psychosis.
- Neuropsychiatric symptoms fluctuated across visits.
- In the affective cluster, depression showed the least visit-to-visit stability.
- In the disinhibited cluster, elation showed the least stability.
Why it matters
Neuropsychiatric symptoms were very common in behavioral variant frontotemporal dementia and fell into four clusters, with some symptoms fluctuating across visits while others persisted. Because some symptoms fluctuate, the authors say they may not be reliable markers of disease progression or stage.
Study details
- Study designlongitudinal study
- Participants354
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Psychiatry and Clinical Neurosciences) |
| Journal's citation record | 1 / 4 | Psychiatry and Clinical Neurosciences: journal h-index 120 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 354 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 10 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Chiadi U. Onyike: h-index 57 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | University of Washington: institution h-index 3,540 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 14 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40079430) |
| Free to read | 2 / 2 | Free to read |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
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