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47/100

✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain scans and imaging

Topic: Brain proteins, microglia and lab models

The median PPA and NPA were 83.4% and 88.9%, respectively, with lower bounds of 2-sided 95% CIs being 50% or greater for all readers. The Fleiss κ-point estimate was 0.8882 (95% CI, 0.8356–0.9409) and the Cohen κ-point estimate was 0.9599 (95% CI, 0.9049–1.000) for all readers, indicating almost perfect inter- and intrareader agreement. Study I7E-AV-A26 successfully validated the feasibility of the FTP visual stratification method, possibly supporting AD staging and prognosis with high inter- and intrareader agreements, confirming the reliability of the method. Future investigations may include expanding the validation dataset, including real-world clinical data from diverse populations, using autopsy confirmation, exploring alternative regions and thresholds for other tau PET stratifications, and assessing differences in treatment response among visually stratified participants enrolled in disease-modifying therapy trials.

Key findings

The median PPA and NPA were 83.4% and 88.9%, respectively, with lower bounds of 2-sided 95% CIs being 50% or greater for all readers.
The Fleiss κ-point estimate was 0.8882 (95% CI, 0.8356–0.9409) and the Cohen κ-point estimate was 0.9599 (95% CI, 0.9049–1.000) for all readers, indicating almost perfect inter- and intrareader agreement.
Study I7E-AV-A26 successfully validated the feasibility of the FTP visual stratification method, possibly supporting AD staging and prognosis with high inter- and intrareader agreements, confirming the reliability of the method.
Future investigations may include expanding the validation dataset, including real-world clinical data from diverse populations, using autopsy confirmation, exploring alternative regions and thresholds for other tau PET stratifications, and assessing differences in treatment response among visually stratified participants enrolled in disease-modifying therapy trials.

Why it matters

This study validated a method where readers visually assess 18F-Flortaucipir PET scans to stratify Alzheimer's disease, finding almost perfect agreement between and within readers. The authors say the method may support staging and prognosis, and that future work could examine treatment response among visually stratified participants in disease-modifying therapy trials.

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Study details

Study designclinical trial
Participants140
Effect size83.4%; 88.9%
Evidence strengthLow

How this study scored 47/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Nuclear Medicine)
Journal's citation record	2 / 4	Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29)
Study design	0 / 12	Design recorded as “clinical trial”, which our rubric does not rank (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	140 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 5 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.7 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	1 / 4	Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Leonardo Iaccarino: h-index 44 (OpenAlex, whole career)
Institution's track record	1 / 3	Eli Lilly (United States): institution h-index 744 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40081955)
Free to read	2 / 2	Free to read
Total	47 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

APA 7th

Tunali, I., Wang, J., Arora, A., Kim, M. J., Shcherbinin, S., Pontecorvo, M. J., et al. (2025). Development and Validation of a 18 F-Flortaucipir PET Visual Stratification Method. Journal of Nuclear Medicine. https://doi.org/10.2967/jnumed.124.268700

Vancouver

Tunali I, Wang J, Arora A, Kim MJ, Shcherbinin S, Pontecorvo MJ, et al. Development and Validation of a 18 F-Flortaucipir PET Visual Stratification Method. Journal of Nuclear Medicine. 2025. doi:10.2967/jnumed.124.268700. PMID: 40081955.

BibTeX

@article{tunali2025-40081955,
  author  = {Tunali, Ilke and Wang, Jian and Arora, Anupa and Kim, Min Jung and Shcherbinin, Sergey and Pontecorvo, Michael J. and Iaccarino, Leonardo},
  title   = {{Development and Validation of a 18 F-Flortaucipir PET Visual Stratification Method}},
  journal = {Journal of Nuclear Medicine},
  year    = {2025},
  doi     = {10.2967/jnumed.124.268700},
  pmid    = {40081955},
  url     = {https://doi.org/10.2967/jnumed.124.268700}
}

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