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Localized Intense Uptake in the Skull on 18 F-Flortaucipir PET/CT
Zhenchun Xu, Xiaojiao Xiang, Yue Feng, Xinlin Shi, Liang Cai. Clinical nuclear medicine, 2025-04-23
Topic: Plasma and spinal-fluid biomarkers
18 F-Flortaucipir, as a classical Tau protein visualizer, has been widely used in the diagnosis of neurodegenerative diseases, especially Alzheimer disease. This report describes a case of intense uptake of 18 F-Flortaucipir at 2 sites of reduced bone mineral density in the skull, but no radioactivity uptake was seen on 18 F-FDG and 18 F-Florbetapir PET/CT imaging at the same lesion sites. The mechanism behind 18 F-Flortaucipir uptake in focal osteopenia remains unclear. This study provides evidence for the mechanism of the above phenomenon.
Key findings
- 18 F-Flortaucipir, as a classical Tau protein visualizer, has been widely used in the diagnosis of neurodegenerative diseases, especially Alzheimer disease.
- This report describes a case of intense uptake of 18 F-Flortaucipir at 2 sites of reduced bone mineral density in the skull, but no radioactivity uptake was seen on 18 F-FDG and 18 F-Florbetapir PET/CT imaging at the same lesion sites.
- The mechanism behind 18 F-Flortaucipir uptake in focal osteopenia remains unclear.
- This study provides evidence for the mechanism of the above phenomenon.
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Study details
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 27 of the 56 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical nuclear medicine) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40263752) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 27 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 27 of the 56 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Xu, Z., Xiang, X., Feng, Y., Shi, X., & Cai, L. (2025). Localized Intense Uptake in the Skull on 18 F-Flortaucipir PET/CT. Clinical nuclear medicine. https://doi.org/10.1097/rlu.0000000000005848
Vancouver
Xu Z, Xiang X, Feng Y, Shi X, Cai L. Localized Intense Uptake in the Skull on 18 F-Flortaucipir PET/CT. Clinical nuclear medicine. 2025. doi:10.1097/rlu.0000000000005848. PMID: 40263752.
BibTeX
@article{xu2025-40263752,
author = {Xu, Zhenchun and Xiang, Xiaojiao and Feng, Yue and Shi, Xinlin and Cai, Liang},
title = {{Localized Intense Uptake in the Skull on 18 F-Flortaucipir PET/CT}},
journal = {Clinical nuclear medicine},
year = {2025},
doi = {10.1097/rlu.0000000000005848},
pmid = {40263752},
url = {https://doi.org/10.1097/rlu.0000000000005848}
}
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