An automated multimodal medical image fusion framework for Alzheimer detection using deep learning

Topic: Amyloid, tau and blood-test diagnosis

Alzheimer’s disease (AD) is a progressive neurodegenerative condition that affects the elderly population. The early detection and diagnosis of AD is critical for achieving effective treatment, as it can greatly improve the patient experience. AD can be viewed through imaging techniques like MRI, PET, and SPECT, providing valuable information about structural and functional changes. These findings are important in understanding this area. However, each imaging modality offers a different perspective. This information can be better collected from several of the other modalities as well as from some others to improve accuracy and reliability in AD detection. By combining information from different imaging modalities, such as MRI, PET, DTI, and fMRI, automated multimodal medical image frameworks aim to create a fused representation that preserves the relevant features from each modality. Convolutional neural networks (CNNs) and generative adversarial networks (GANs), among other deep learning techniques, have been prevalent in these frameworks for learning discriminative and informative features from multi-modal data. In this paper, The Alzheimer’s Disease Neuroimaging Initiative (ADNI) is used for experimental analysis. The proposed work gives 98.94% of accuracy and 1.06% of error which is greater than the existing approaches.

Key findings

• These findings are important in understanding this area.

Why it matters

This study combined different types of brain scans using deep learning to detect Alzheimer's disease, reporting 98.94% accuracy. It is a detection method only and does not test any treatment, cure, or prevention for Alzheimer's disease.

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Study details

• Effect size98.94%; 1.06%
• Evidence strengthLow

Read the original

• DOI: 10.61091/jcmcc126-04
• Original source →
• Free full text: Journal of Combinatorial Mathematics and Combinatorial Computing →

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

@article{beatrice2025-f2cfdadd,
  author  = {Beatrice, S. and Janaki Meena, M. and Dhivviyanandam, I},
  title   = {{An automated multimodal medical image fusion framework for Alzheimer detection using deep learning}},
  journal = {Journal of Combinatorial Mathematics and Combinatorial Computing},
  year    = {2025},
  doi     = {10.61091/jcmcc126-04},
  url     = {https://doi.org/10.61091/jcmcc126-04}
}

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