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Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays
Shin Kurose, Sho Moriguchi, Manabu Kubota, Kenji Tagai, Yuki Momota, Masanori Ichihashi, Yasunori Sano, Hironobu Endo et al.. Alzheimer s & Dementia, 2025-06-01
Topic: Brain proteins, microglia and lab models
LLMD participants were more likely to be tau PET and Aβ PET positive than HCs. The PET results were supported by the post mortem results that showed a higher likelihood of diverse tauopathies in patients with late-life mania or depression than those without. Our PET and autopsy assays suggest that AD and diverse non-AD tau pathologies might underlie the neuropathological basis of some LLMD cases. HIGHLIGHTS: Late-life mood disorders (LLMDs) may represent prodromal states of dementia. The neuropathological basis of LLMDs remains unclear. LLMD subjects were highly likely to be tau positron emission tomography (PET) positive. Brain bank data supported our PET results. Alzheimer's disease (AD) and diverse non-AD tau pathologies can contribute to LLMDs.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Kurose, S., Moriguchi, S., Kubota, M., Tagai, K., Momota, Y., Ichihashi, M., et al. (2025). Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70195
Vancouver
Kurose S, Moriguchi S, Kubota M, Tagai K, Momota Y, Ichihashi M, et al. Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70195. PMID: 40488253.
BibTeX
@article{kurose2025-40488253,
author = {Kurose, Shin and Moriguchi, Sho and Kubota, Manabu and Tagai, Kenji and Momota, Yuki and Ichihashi, Masanori and Sano, Yasunori and Endo, Hironobu and others},
title = {{Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70195},
pmid = {40488253},
url = {https://doi.org/10.1002/alz.70195}
}
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Key findings
- LLMD participants were more likely to be tau PET and Aβ PET positive than HCs.
- The PET results were supported by the post mortem results that showed a higher likelihood of diverse tauopathies in patients with late-life mania or depression than those without.
- Our PET and autopsy assays suggest that AD and diverse non-AD tau pathologies might underlie the neuropathological basis of some LLMD cases.
- HIGHLIGHTS: Late-life mood disorders (LLMDs) may represent prodromal states of dementia.
- The neuropathological basis of LLMDs remains unclear.
Why it matters
Using PET and autopsy data, this study found that people with late-life mood disorders were more likely to be tau PET and amyloid PET positive and to show diverse tauopathies than controls. It suggests these mood disorders may sometimes be early states of dementia, but reports no treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 9 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Keisuke Takahata: h-index 27 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Toronto: institution h-index 1,923 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 10 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40488253) |
| Free to read | 2 / 2 | Free to read |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
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