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Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury
Yuna Li, Shan Tian, Yuan Qiao, Chaohua Cong, Junting Yang, Shanshan Cao, Xirui Zhu, Lei Zhao et al.. Journal of Cachexia Sarcopenia and Muscle, 2025-06-01
Topic: Brain proteins, microglia and lab models
Sensitivity analyses were performed to validate the robustness of the linear regression results. Results A greater HGS was linearly associated with a smaller WMH volume (β = −0.006642, p < 0.001) and fuller microstructure (p < 0.001). These relationships persisted when stratified by sex or age decade and were supported by the results of the longitudinal analysis (β = −26.4, p = 0.0145). Conclusions Our study revealed that greater HGS was linearly associated with reduced WMH volume and less white matter microstructural injury, mediated by STT.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Li, Y., Tian, S., Qiao, Y., Cong, C., Yang, J., Cao, S., et al. (2025). Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury. Journal of Cachexia Sarcopenia and Muscle. https://doi.org/10.1002/jcsm.13833
Vancouver
Li Y, Tian S, Qiao Y, Cong C, Yang J, Cao S, et al. Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury. Journal of Cachexia Sarcopenia and Muscle. 2025. doi:10.1002/jcsm.13833. PMID: 40464223.
BibTeX
@article{li2025-40464223,
author = {Li, Yuna and Tian, Shan and Qiao, Yuan and Cong, Chaohua and Yang, Junting and Cao, Shanshan and Zhu, Xirui and Zhao, Lei and others},
title = {{Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury}},
journal = {Journal of Cachexia Sarcopenia and Muscle},
year = {2025},
doi = {10.1002/jcsm.13833},
pmid = {40464223},
url = {https://doi.org/10.1002/jcsm.13833}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Sensitivity analyses were performed to validate the robustness of the linear regression results.
- Results A greater HGS was linearly associated with a smaller WMH volume (β = −0.006642, p < 0.001) and fuller microstructure (p < 0.001).
- These relationships persisted when stratified by sex or age decade and were supported by the results of the longitudinal analysis (β = −26.4, p = 0.0145).
- Conclusions Our study revealed that greater HGS was linearly associated with reduced WMH volume and less white matter microstructural injury, mediated by STT.
Why it matters
Greater handgrip strength was linked to less white matter hyperintensity volume and less white matter injury, with testosterone partly mediating this relationship. This is an observational finding and does not show that increasing handgrip strength or testosterone prevents dementia.
Study details
- Study designlongitudinal study
- Participants832
- Effect size50.9%; 1.06%; 1.57%
- Evidence strengthModerate
How this study scored 56/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 54 of the 96 points we could judge it on, which is 56 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Cachexia Sarcopenia and Muscle) |
| Journal's citation record | 2 / 4 | Journal of Cachexia Sarcopenia and Muscle: journal h-index 150 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 832 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 7 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 3.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Jing Jing Su holds only 4 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 1 / 3 | Shanghai Jiao Tong University: institution h-index 975 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40464223) |
| Free to read | 2 / 2 | Free to read |
| Points | 54 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 54 of the 96 points we could judge it on is 56 out of 100. |
| Total | 56 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1002/jcsm.13833
- PubMed: 40464223
- Original source →
- Free full text: Journal of Cachexia Sarcopenia and Muscle →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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