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Evaluating Genomic and Clinical Risk Factors for Alzheimer's Disease in Individuals with Hypertension
Kim Elizabeth, Zhang Kevin, Abdi Miski, Li Wei Tse, Xin Ruomin, Wang-Rodriguez Jessica, Ongkeko Weg M. Biomedicines, 2025-06-26
Topic: Amyloid, tau and blood-test diagnosis
Obesity and Area Deprivation Index, a measure of socioeconomic status, were significantly associated with elevated AD risk within the hypertensive cohort. GWAS analysis identified six SNVs significantly associated with AD development among the hypertensive cohort. Our findings suggest that among hypertensive individuals, comorbid obesity and the Area Deprivation Index confer greater AD risk. These results highlight the critical need for obesity prevention and management strategies as part of Alzheimer's risk reduction efforts.
Key findings
- Obesity and Area Deprivation Index, a measure of socioeconomic status, were significantly associated with elevated AD risk within the hypertensive cohort.
- GWAS analysis identified six SNVs significantly associated with AD development among the hypertensive cohort.
- Our findings suggest that among hypertensive individuals, comorbid obesity and the Area Deprivation Index confer greater AD risk.
- These results highlight the critical need for obesity prevention and management strategies as part of Alzheimer's risk reduction efforts.
Why it matters
Among people with high blood pressure, obesity and neighborhood disadvantage were linked to higher Alzheimer's risk, and six genetic variants were also associated with the disease. The authors say these findings point to obesity prevention and management as part of efforts to reduce Alzheimer's risk in this group.
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Study details
- Study designretrospective cohort
- Participants1,862
- Evidence strengthModerate
How this study scored 63/100
Published in a peer-reviewed journal, and it is a retrospective cohort study, reconstructed from past records. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here and still being cited, so those were left out: it earned 45 of the 72 points we could judge it on, which is 63 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Biomedicines) |
| Journal's citation record | 1 / 4 | Biomedicines: journal h-index 133 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A retrospective cohort study, reconstructed from past records |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,862 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | Citation count not trusted: 6 of 9 library studies citing it were published more than a year before it - a sign OpenAlex merged several works under this DOI — left out of this score |
| Citations per year | — / 5 | Citation count not trusted (see above) — left out of this score |
| Impact for its field and year | — / 6 | Citation count not trusted (see above) — left out of this score |
| Cited by studies here | — / 6 | Library citations not trusted (see above) — left out of this score |
| Still being cited | — / 4 | Citation count not trusted (see above) — left out of this score |
| Senior author's track record | 2 / 4 | Last-listed author Weg M. Ongkeko: h-index 34 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,912 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40564227) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 45 / 72 | Scored on 15 of 20 parts. We have no data for the rest, so they are left out: 45 of the 72 points we could judge it on is 63 out of 100. |
| Total | 63 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Elizabeth, K., Kevin, Z., Miski, A., Tse, L. W., Ruomin, X., Jessica, W.-R., et al. (2025). Evaluating Genomic and Clinical Risk Factors for Alzheimer's Disease in Individuals with Hypertension. Biomedicines. https://doi.org/10.3390/biomedicines13061508
Vancouver
Elizabeth K, Kevin Z, Miski A, Tse LW, Ruomin X, Jessica W.-R, et al. Evaluating Genomic and Clinical Risk Factors for Alzheimer's Disease in Individuals with Hypertension. Biomedicines. 2025. doi:10.3390/biomedicines13061508. PMID: 40564227.
BibTeX
@article{elizabeth2025-40564227,
author = {Elizabeth, Kim and Kevin, Zhang and Miski, Abdi and Tse, Li Wei and Ruomin, Xin and Jessica, Wang-Rodriguez and Ongkeko Weg, M.},
title = {{Evaluating Genomic and Clinical Risk Factors for Alzheimer's Disease in Individuals with Hypertension}},
journal = {Biomedicines},
year = {2025},
doi = {10.3390/biomedicines13061508},
pmid = {40564227},
url = {https://doi.org/10.3390/biomedicines13061508}
}
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