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System readiness and the patient care pathway for Alzheimer's disease diagnosis and treatment
Snider B Joy, Biffi Alessandro, Bozeat Sasha, Clevenger Carolyn, Farrar Gill, Gitelman Darren, Kolster Rachel, Mattke Soeren et al.. Alzheimer's & dementia (New York, N. Y.), 2025-06-24
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
Promising therapeutic interventions that target the underlying pathophysiology are changing the landscape of Alzheimer's disease (AD) research. The AD care pathway must be transformed to meet the challenge of bringing these new therapies to the increasing number of people living with AD within the existing healthcare framework. Challenges include identifying patients who may benefit from treatment interventions early in the course of the disease, ensuring that diagnostic tools are accessible and accurate, and developing capabilities to monitor the effectiveness of interventions over time. These challenges must be addressed at all levels, from primary care settings to tertiary treatment centers; this will require collaborative efforts between health systems, drug manufacturers, and research institutions to navigate this evolving landscape and ensure system readiness for patients and their families with AD. The Spring 2024 Alzheimer's Association Research Roundtable (AARR) meeting gathered industry representatives and clinicians to discuss insights, challenges, and solutions that will help researchers and health systems identify patients in the early stages of AD and deliver emerging therapies efficiently and safely. In this paper, we provide highlights from the Spring 2024 AARR meeting.
What this study adds
Evidence grade: Low
This paper reports on a meeting about how health systems can identify patients early and deliver emerging Alzheimer's therapies safely. It does not present new treatment, cure, or prevention results, but describes challenges in the care pathway that must be addressed.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Joy, S. B., Alessandro, B., Sasha, B., Carolyn, C., Gill, F., Darren, G., et al. (2025). System readiness and the patient care pathway for Alzheimer's disease diagnosis and treatment. Alzheimer's & dementia (New York, N. Y.). https://doi.org/10.1002/trc2.70094
Vancouver
Joy SB, Alessandro B, Sasha B, Carolyn C, Gill F, Darren G, et al. System readiness and the patient care pathway for Alzheimer's disease diagnosis and treatment. Alzheimer's & dementia (New York, N. Y.). 2025. doi:10.1002/trc2.70094. PMID: 40547330.
BibTeX
@article{joy2025-40547330,
author = {Joy, Snider B and Alessandro, Biffi and Sasha, Bozeat and Carolyn, Clevenger and Gill, Farrar and Darren, Gitelman and Rachel, Kolster and Soeren, Mattke and others},
title = {{System readiness and the patient care pathway for Alzheimer's disease diagnosis and treatment}},
journal = {Alzheimer's \& dementia (New York, N. Y.)},
year = {2025},
doi = {10.1002/trc2.70094},
pmid = {40547330},
url = {https://doi.org/10.1002/trc2.70094}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- The AD care pathway must be transformed to meet the challenge of bringing these new therapies to the increasing number of people living with AD within the existing healthcare framework.
- Challenges include identifying patients who may benefit from treatment interventions early in the course of the disease, ensuring that diagnostic tools are accessible and accurate, and developing capabilities to monitor the effectiveness of interventions over time.
- These challenges must be addressed at all levels, from primary care settings to tertiary treatment centers; this will require collaborative efforts between health systems, drug manufacturers, and research institutions to navigate this evolving landscape and ensure system readiness for patients and their families with AD.
- The Spring 2024 Alzheimer's Association Research Roundtable (AARR) meeting gathered industry representatives and clinicians to discuss insights, challenges, and solutions that will help researchers and health systems identify patients in the early stages of AD and deliver emerging therapies efficiently and safely.
- In this paper, we provide highlights from the Spring 2024 AARR meeting.
Why it matters
This paper reports on a meeting about how health systems can identify patients early and deliver emerging Alzheimer's therapies safely. It does not present new treatment, cure, or prevention results, but describes challenges in the care pathway that must be addressed.
Study details
- Evidence strengthLow
How this study scored 37/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (New York, N. Y.)) |
| Journal's citation record | 1 / 4 | Alzheimer s & Dementia Translational Research & Clinical Interventions: journal h-index 84 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-17) |
| Citations per year | 0 / 5 | 0.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Christopher J. Weber: h-index 15 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,236 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 19 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40547330) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 37 / 100 | — |
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