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43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Getting a diagnosis

Topic: Brain proteins, microglia and lab models

We included 71 DLB (76.8 ± 7.4 years old, 25 females) and 71 age- and sex-matched AD patients (and 75.2 ± 5.3 years old, 27 females). Probable CAA, according to current Boston 2.0 criteria, was observed in 22.5% of DLB and 35.2% of AD patients, while any (probable + possible) CAA rate was higher in the two groups (71.8% and 91.5%, respectively). A moderate/severe HTNA was present in 45% of DLB and 28.2% of AD patients. When comparing the two groups, DLB presented with higher HTNA score (p =.012), while AD patients had higher prevalence of any CAA (p =.002). Patients with DLB had a greater PVS burden in the basal ganglia (p =.011) and centrum semiovale (p =.004) and higher number of deep microbleeds (p =.004). Certain HTNA-related features were more pronounced at dementia stage, with respect to mild cognitive impairment. No association was observed between CVRF and HTNA. Regarding the association between CSVD and cognition, only deep microbleeds count was related to MoCA in DLB patients. DLB or AD patients present with high CSVD burden and differ in terms of features and subtype. Patients with DLB present with increased HTNA, PVS load and deep microbleeds, while patients with AD present with a higher any CAA prevalence. CSVD might impact global cognition.

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APA 7th

Bommarito, G., Griffa, A., Michel, P., Caroline, H., Salvioni, C. P., Pistocchi, S., et al. (2025). Cerebral small vessel disease in memory center patients with dementia with lewy bodies and Alzheimer’s disease. Alzheimer s Research & Therapy. https://doi.org/10.1186/s13195-025-01805-8

Vancouver

Bommarito G, Griffa A, Michel P, Caroline H, Salvioni CP, Pistocchi S, et al. Cerebral small vessel disease in memory center patients with dementia with lewy bodies and Alzheimer’s disease. Alzheimer s Research & Therapy. 2025. doi:10.1186/s13195-025-01805-8. PMID: 40646592.

BibTeX

@article{bommarito2025-40646592,
  author  = {Bommarito, Giulia and Griffa, Alessandra and Michel, Patrik and Caroline, Hall and Salvioni, Chiabotti Paolo and Pistocchi, Silvia and Alemán-Gómez, Yasser and Damian, Daniel and others},
  title   = {{Cerebral small vessel disease in memory center patients with dementia with lewy bodies and Alzheimer’s disease}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01805-8},
  pmid    = {40646592},
  url     = {https://doi.org/10.1186/s13195-025-01805-8}
}

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Key findings

We included 71 DLB (76.8 ± 7.4 years old, 25 females) and 71 age- and sex-matched AD patients (and 75.2 ± 5.3 years old, 27 females).
Probable CAA, according to current Boston 2.0 criteria, was observed in 22.5% of DLB and 35.2% of AD patients, while any (probable + possible) CAA rate was higher in the two groups (71.8% and 91.5%, respectively).
A moderate/severe HTNA was present in 45% of DLB and 28.2% of AD patients.
When comparing the two groups, DLB presented with higher HTNA score (p =.012), while AD patients had higher prevalence of any CAA (p =.002).
Patients with DLB had a greater PVS burden in the basal ganglia (p =.011) and centrum semiovale (p =.004) and higher number of deep microbleeds (p =.004).

Why it matters

This study found that patients with dementia with Lewy bodies and Alzheimer's disease both have high cerebral small vessel disease burden but differ in features, with dementia with Lewy bodies showing more enlarged perivascular spaces and deep microbleeds. It describes differences in disease features rather than testing any treatment or prevention.

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Study details

Participants71
Effect size22.5%; 35.2%; 71.8%
Evidence strengthLow

How this study scored 43/100

Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s Research & Therapy)
Journal's citation record	1 / 4	Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	71 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Gilles Allali: h-index 51 (OpenAlex, whole career)
Institution's track record	1 / 3	École Polytechnique Fédérale de Lausanne: institution h-index 1,186 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40646592)
Free to read	2 / 2	Free to read
Total	43 / 100	—

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