Home › Research › Prevention and risk
Aging and Alcohol Withdrawal Escalate CNS Hyperexcitability Across the Lifespan
Matthews DB, Staebell L, Feller S, Kendrick J, Hartwig J, Riley A, II MT, Johnson K et al.. Research Square, 2026-09-24
Topic: Brain imaging, connectivity and assessment
Central Nervous System (CNS) hyperexcitability is increased during aging and also during alcohol withdrawal. Furthermore, increased neural activity during aging is a biomarker for Alzheimer’s disease onset. However, the interaction of aging and alcohol withdrawal across the lifespan on neural hyperexcitability has yet to be investigated. CNS hyperexcitability at baseline and post-alcohol was determined via handling induced convulsions in C57BL/6J, DBA/2J and A/J female and male mice across the lifespan. Aging and alcohol significantly increased CNS hyperexcitability in an age, strain, and sex dependent manner, demonstrating alcohol exacerbates aging related CNS hyperexcitability.
Key findings
- Aging and alcohol significantly increased CNS hyperexcitability in an age, strain, and sex dependent manner, demonstrating alcohol exacerbates aging related CNS hyperexcitability.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Evidence strengthLow
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 21 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 13 of the 62 points we could judge it on, which is 21 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (Research Square) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 13 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 13 of the 62 points we could judge it on is 21 out of 100. |
| Total | 21 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Matthews, D. B., Staebell, L., Feller, S., Kendrick, J., Hartwig, J., Riley, A., et al. (2026). Aging and Alcohol Withdrawal Escalate CNS Hyperexcitability Across the Lifespan. Research Square. https://doi.org/10.21203/rs.3.rs-10907903/v1
Vancouver
Matthews DB, Staebell L, Feller S, Kendrick J, Hartwig J, Riley A, et al. Aging and Alcohol Withdrawal Escalate CNS Hyperexcitability Across the Lifespan. Research Square. 2026. doi:10.21203/rs.3.rs-10907903/v1.
BibTeX
@article{matthews2026-066e4624,
author = {Matthews, D. B. and Staebell, L. and Feller, S. and Kendrick, J. and Hartwig, J. and Riley, A. and II, M. T. and Johnson, K. and others},
title = {{Aging and Alcohol Withdrawal Escalate CNS Hyperexcitability Across the Lifespan}},
journal = {Research Square},
year = {2026},
doi = {10.21203/rs.3.rs-10907903/v1},
url = {https://doi.org/10.21203/rs.3.rs-10907903/v1}
}
Related studies in Prevention and risk
Also tagged “dendritic”
287 studies in the library carry the topic tag “dendritic”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 287 tagged studies.