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44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Mild cognitive impairment

Topic: Amyloid, tau and blood-test diagnosis

To the Editor: With the aging of the population, the prevalence of Alzheimer’s disease (AD) has increased significantly. Herein, we investigated the difference in brain microstructural changes in patients with AD and MCI using QSM and VBM, combined with neuropsychological test results, to evaluate the diagnostic value of QSM and VBM. General information and blood collection results of all study subjects were homogenous and consistent [Supplementary Table 2, https://links.lww.com/CM9/C502]. Specific scale items and results are shown in Supplementary Table 3, https://links.lww.com/CM9/C502. Results are displayed as mean ± standard deviation. For multiple comparisons, the least significant difference and Tamhane methods were used for groups with uniform and unequal variance, respectively. Differences in brain regions with >20 voxel levels were considered statistically significant, and the results were presented by xjView (version 9.x, http://www.alivelearn.net/xjview). We performed subsequent correlation analyses of the values of the five ROIs that differed in SUS and the GMV% of the four ROIs that differed in GMV% with the neuropsychological test results, plotting the results as heat maps [Supplementary Figure 2, https://links.lww.com/CM9/C502]. The comparison of basic information and blood test results among the three groups revealed no significant differences. These results indicated that the SUS in the left globus pallidus and putamen may be imaging biomarkers for AD diagnosis. No statistically significant differences in SUS were observed among the three groups in other subcortical or cortical brain regions. The inconsistent findings of SUS in the hippocampal and cortical regions may have arisen because the regions with significant differential sensitivities in SUS are at the limbic threshold of the brain where the ROI is segmented, leading to inaccurate measurement of SUS. The above results suggest that the basal ganglia comprises the primary brain region involved in iron deposition in AD and iron deposition increases progressively with disease progression. Using VBM, we found that the GMV% in the right hippocampus, left hippocampus, right middle temporal gyrus, and right caudate decreased progressively among all three groups, indicating significant gray matter atrophy in these regions. Researchers have speculated that disruption of iron homeostasis is associated with AD pathology and neuronal loss.[5] Consequently, we used the VBM method to obtain GMV d

Key findings

To the Editor: With the aging of the population, the prevalence of Alzheimer’s disease (AD) has increased significantly.
Herein, we investigated the difference in brain microstructural changes in patients with AD and MCI using QSM and VBM, combined with neuropsychological test results, to evaluate the diagnostic value of QSM and VBM.
General information and blood collection results of all study subjects were homogenous and consistent [Supplementary Table 2, https://links.lww.com/CM9/C502].
Specific scale items and results are shown in Supplementary Table 3, https://links.lww.com/CM9/C502.
Results are displayed as mean ± standard deviation.

Why it matters

This letter compared quantitative susceptibility mapping and voxel-based morphometry in people with Alzheimer's disease and mild cognitive impairment, combined with neuropsychological tests, to evaluate their diagnostic value. It does not test a treatment or cure, and the available text does not report clear findings on diagnosis.

Study details

Study designlongitudinal study
Participants20
Evidence strengthModerate

How this study scored 44/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Chinese Medical Journal)
Journal's citation record	1 / 4	Chinese Medical Journal: journal h-index 94 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	20 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.3 citations a year over 3 year(s) since 2025
Impact for its field and year	1 / 6	Cited 0.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Yusong Ge: h-index 13 (OpenAlex, whole career)
Institution's track record	0 / 3	Dalian Medical University: institution h-index 265 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40671196)
Free to read	2 / 2	Free to read
Total	44 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Fu, Y., Chen, H., Lou, S., Guo, Y., Elzahra, F., Ren, H., et al. (2025). Diagnostic value and difference of quantitative susceptibility mapping and voxel-based morphological analysis in patients with Alzheimer’s disease and mild cognitive impairment. Chinese Medical Journal. https://doi.org/10.1097/cm9.0000000000003683

Vancouver

Fu Y, Chen H, Lou S, Guo Y, Elzahra F, Ren H, et al. Diagnostic value and difference of quantitative susceptibility mapping and voxel-based morphological analysis in patients with Alzheimer’s disease and mild cognitive impairment. Chinese Medical Journal. 2025. doi:10.1097/cm9.0000000000003683. PMID: 40671196.

BibTeX

@article{fu2025-40671196,
  author  = {Fu, Yu and Chen, Honghai and Lou, Shiyun and Guo, Yunchu and Elzahra, Fatima and Ren, Hongling and Wang, Hairong and Zeng, Qingyan and others},
  title   = {{Diagnostic value and difference of quantitative susceptibility mapping and voxel-based morphological analysis in patients with Alzheimer’s disease and mild cognitive impairment}},
  journal = {Chinese Medical Journal},
  year    = {2025},
  doi     = {10.1097/cm9.0000000000003683},
  pmid    = {40671196},
  url     = {https://doi.org/10.1097/cm9.0000000000003683}
}

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