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50/100

✓ Peer-reviewed alzhub usefulness score 50 out of 100. How common it is

Topic: Amyloid, tau and blood-test diagnosis

, respectively (p-values < 0.05), with p-tau217 demonstrating the highest classification accuracy for Aβ-PET status (AUC = 0.94). Plasma p-tau181 and p-tau217 showed significant associations with tau-PET status (AOR: 1.50 and 22.24, respectively (p-values < 0.05), with comparable classification accuracies for tau-PET status (AUC = 0.74 and 0.70, respectively). Only plasma NfL showed significant association with neurodegeneration based on cortical thickness (AOR = 1.09, p-value < 0.05). Our findings highlight the potential of plasma p-tau217 as a biomarker for brain Aβ and tau pathophysiology, p-tau181 for tau abnormalities, and NfL for neurodegeneration in the community.

Key findings

, respectively (p-values < 0.05), with p-tau217 demonstrating the highest classification accuracy for Aβ-PET status (AUC = 0.94).
Plasma p-tau181 and p-tau217 showed significant associations with tau-PET status (AOR: 1.50 and 22.24, respectively (p-values < 0.05), with comparable classification accuracies for tau-PET status (AUC = 0.74 and 0.70, respectively).
Only plasma NfL showed significant association with neurodegeneration based on cortical thickness (AOR = 1.09, p-value < 0.05).
Our findings highlight the potential of plasma p-tau217 as a biomarker for brain Aβ and tau pathophysiology, p-tau181 for tau abnormalities, and NfL for neurodegeneration in the community.

Why it matters

In a dementia-free population-based cohort, plasma p-tau217 was the best blood marker for brain amyloid status, p-tau181 and p-tau217 were associated with tau status, and NfL was associated with neurodegeneration. The findings concern biomarkers for detecting brain changes, not treating, curing, or preventing dementia.

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Study details

Participants113
Effect sizeAUC = 0.94; AOR: 1.50; AUC = 0.74
Evidence strengthModerate

How this study scored 50/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s Research & Therapy)
Journal's citation record	1 / 4	Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	113 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 11 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	3.7 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 7.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Thomas K. Karikari: h-index 66 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Pittsburgh: institution h-index 1,470 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40713737)
Free to read	2 / 2	Free to read
Total	50 / 100	—

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Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Dresse, M. T., Ferreira, P. C., Prasadan, A., Diaz, J. L., Zeng, X., Bellaver, B., et al. (2025). Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort. Alzheimer s Research & Therapy. https://doi.org/10.1186/s13195-025-01803-w

Vancouver

Dresse MT, Ferreira PC, Prasadan A, Diaz JL, Zeng X, Bellaver B, et al. Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort. Alzheimer s Research & Therapy. 2025. doi:10.1186/s13195-025-01803-w. PMID: 40713737.

BibTeX

@article{dresse2025-40713737,
  author  = {Dresse, Menayit Tamrat and Ferreira, Pâmela C.L. and Prasadan, Akshay and Diaz, Jihui L. and Zeng, Xuemei and Bellaver, Bruna and Povala, Guilherme and Villemagne, Victor L. and others},
  title   = {{Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01803-w},
  pmid    = {40713737},
  url     = {https://doi.org/10.1186/s13195-025-01803-w}
}

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