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49/100

✓ Peer-reviewed alzhub usefulness score 49 out of 100. Brain scans and imaging

Topic: Amyloid, tau and blood-test diagnosis

Results Significant differences in TMT measurements were observed by age and sex, with thinner TMT found in females and older adults. TMT was significantly associated with ASMI, handgrip strength and mobility. Among cognitive domains, TMT was most closely associated with performance on the Auditory Verbal Learning Test recognition (p < 0.05). Stratified analyses revealed that the correlation between TMT and MoCA‐B remained significant in MCI participants but not in AD participants. Multivariable logistic regression analysis showed that higher TMT was significantly associated with a lower risk of MCI (OR: 0.494, 95% CI: 0.287–0.849, p < 0.05) and a reduced likelihood of functional dependence (OR: 0.791, 95% CI: 0.670–0.935, p < 0.01). Furthermore, TMT was lower in participants with higher brain tau deposition and was negatively associated with tau PET Braak stages (both p < 0.01). Conclusions A decline in TMT was associated with worse cognitive function, increased cerebral tau deposition and impaired functional performance.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Zhu, Y., Ke, Y., Ren, C., Zhu, J., Zhang, Z., Cui, L., et al. (2025). Temporal Muscle Thickness as a New Biomarker: Its Association With Alzheimer Pathology and Cognitive Impairment in Chinese Adults. Journal of Cachexia Sarcopenia and Muscle. https://doi.org/10.1002/jcsm.70030

Vancouver

Zhu Y, Ke Y, Ren C, Zhu J, Zhang Z, Cui L, et al. Temporal Muscle Thickness as a New Biomarker: Its Association With Alzheimer Pathology and Cognitive Impairment in Chinese Adults. Journal of Cachexia Sarcopenia and Muscle. 2025. doi:10.1002/jcsm.70030. PMID: 40717521.

BibTeX

@article{zhu2025-40717521,
  author  = {Zhu, Yunxia and Ke, Yingying and Ren, Chenxi and Zhu, Jiehua and Zhang, Zhen and Cui, Liang and Li, Yuehua and Xie, Fang and others},
  title   = {{Temporal Muscle Thickness as a New Biomarker: Its Association With Alzheimer Pathology and Cognitive Impairment in Chinese Adults}},
  journal = {Journal of Cachexia Sarcopenia and Muscle},
  year    = {2025},
  doi     = {10.1002/jcsm.70030},
  pmid    = {40717521},
  url     = {https://doi.org/10.1002/jcsm.70030}
}

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Key findings

Results Significant differences in TMT measurements were observed by age and sex, with thinner TMT found in females and older adults.
TMT was significantly associated with ASMI, handgrip strength and mobility.
Among cognitive domains, TMT was most closely associated with performance on the Auditory Verbal Learning Test recognition (p < 0.05).
Stratified analyses revealed that the correlation between TMT and MoCA‐B remained significant in MCI participants but not in AD participants.
Multivariable logistic regression analysis showed that higher TMT was significantly associated with a lower risk of MCI (OR: 0.494, 95% CI: 0.287–0.849, p < 0.05) and a reduced likelihood of functional dependence (OR: 0.791, 95% CI: 0.670–0.935, p < 0.01).

Why it matters

This study found that thinner temporal muscle thickness was associated with worse cognitive function, higher brain tau deposition, and impaired functional performance in Chinese adults. The link between temporal muscle thickness and cognitive scores remained significant in people with mild cognitive impairment but not in those with Alzheimer's disease.

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Study details

Participants801
Effect sizeOR: 0.494; OR: 0.791
Evidence strengthLow

How this study scored 49/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Cachexia Sarcopenia and Muscle)
Journal's citation record	2 / 4	Journal of Cachexia Sarcopenia and Muscle: journal h-index 150 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	801 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 9 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	3.0 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 5.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Qihao Guo: h-index 45 (OpenAlex, whole career)
Institution's track record	1 / 3	Fudan University: institution h-index 954 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40717521)
Free to read	2 / 2	Free to read
Total	49 / 100	—

What each of these 20 components measures, and what this score is not →

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