Home › Research › Tau biomarkers
Alcohol consumption and cerebrospinal fluid biomarkers for preclinical alzheimer's disease in a population-based sample of 70-year-olds
Kern S, Skillbäck T, Zetterberg H, Dittrich A, Ahlner F, Zettergren A, Waern M, Seidu NM et al.. Alzheimer's research & therapy, 2025-07-25
Topic: Amyloid, tau and blood-test diagnosis
Background It is largely unknown how alcohol use affects the risk of Alzheimer`s disease (AD). Therefore, studies on the influence of alcohol use on cerebrospinal fluid (CSF) biomarkers for the earliest preclinical phase of AD are needed. Methods This was a cross-sectional cohort study.
Key findings
- Therefore, studies on the influence of alcohol use on cerebrospinal fluid (CSF) biomarkers for the earliest preclinical phase of AD are needed.
- Methods This was a cross-sectional cohort study.
- The sample (n = 301) was derived from the 2014-2016 examinations of the Gothenburg H70 Birth Cohort Studies.
- The study cohort consisted of 301 70-year-old women and men, where of 246 cognitively unimpaired and 55 with mild cognitive deficits.
Why it matters
This cross-sectional cohort study examined how alcohol use relates to CSF biomarkers for the earliest preclinical phase of Alzheimer's disease in 70-year-olds. It reports associations with biomarkers only and does not establish that alcohol use treats, cures or prevents the disease.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Study designcohort study
- Participants301
- Evidence strengthModerate
How this study scored 51/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer's research & therapy) |
| Journal's citation record | 1 / 4 | Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 301 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Ingmar Gr. Skoog: h-index 105 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40713707) |
| Free to read | 2 / 2 | Free to read |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13195-025-01819-2
- PubMed: 40713707
- Original source →
- Free full text: Alzheimer s Research & Therapy →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Kern, S., Skillbäck, T., Zetterberg, H., Dittrich, A., Ahlner, F., Zettergren, A., et al. (2025). Alcohol consumption and cerebrospinal fluid biomarkers for preclinical alzheimer's disease in a population-based sample of 70-year-olds. Alzheimer's research & therapy. https://doi.org/10.1186/s13195-025-01819-2
Vancouver
Kern S, Skillbäck T, Zetterberg H, Dittrich A, Ahlner F, Zettergren A, et al. Alcohol consumption and cerebrospinal fluid biomarkers for preclinical alzheimer's disease in a population-based sample of 70-year-olds. Alzheimer's research & therapy. 2025. doi:10.1186/s13195-025-01819-2. PMID: 40713707.
BibTeX
@article{kern2025-40713707,
author = {Kern, S. and Skillbäck, T. and Zetterberg, H. and Dittrich, A. and Ahlner, F. and Zettergren, A. and Waern, M. and Seidu, N. M. and others},
title = {{Alcohol consumption and cerebrospinal fluid biomarkers for preclinical alzheimer's disease in a population-based sample of 70-year-olds}},
journal = {Alzheimer's research \& therapy},
year = {2025},
doi = {10.1186/s13195-025-01819-2},
pmid = {40713707},
url = {https://doi.org/10.1186/s13195-025-01819-2}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Related studies in Tau biomarkers
Also tagged “biomarkers”
821 studies in the library carry the topic tag “biomarkers”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 821 tagged studies.